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Virus protease

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(New page: Crystal Structure of HIV-1 protease 1odw {{STRUCTURE_1odw| PDB=1odw | SIZE=300| S |right|CAPTION=HIV-1 protease 1odw }} '''Virus proteases''...)
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[[Image:1odw.png|left|200px|thumb|Crystal Structure of HIV-1 protease [[1odw]]]]
[[Image:1odw.png|left|200px|thumb|Crystal Structure of HIV-1 protease [[1odw]]]]
{{STRUCTURE_1odw| PDB=1odw | SIZE=300| S |right|CAPTION=HIV-1 protease [[1odw]] }}
{{STRUCTURE_1odw| PDB=1odw | SIZE=300| S |right|CAPTION=HIV-1 protease [[1odw]] }}
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== 3D Structures of Virus proteases ==
== 3D Structures of Virus proteases ==
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===HIV-1===
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[[3ixo]] - HIV1-PR subtype A<br />
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[[1odx]], [[ 2hb2]], [[ 2hb4]], [[ 2pc0]] - HIV1-PR (mutant) <br />
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[[1rpi]], [[ 1rq9]], [[ 1tw7]] - HIV1-PR (drug-resistant mutant) <br />
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[[1odw]], [[ 3kf1]] - HIV1-PR
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===HIV-1 complexes===
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[[1hsg]], [[ 1hsh]], [[ 1hsi]], [[ 3oxc]], [[ 3ekv]], [[ 3ekx]], [[ 3eky]], [[ 3el1]], [[ 1ohr]] - HIV1-PR + antiviral drug<br />
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[[1aid]], [[ 1qbr]], [[ 1qbs]], [[ 1qbt]], [[ 1qbu]], [[ 3mxe]], [[ 3m9f ]], [[ 3kf0]], [[ 3kf1]], [[ 3kfn]], [[ 3kfp]], [[ 3kfr]], [[ 3kfs]], [[ 2wkz]], [[ 2wl0]], [[ 3gga]], [[ 3ggv]], [[ 3ggx]], [[ 2uxz]], [[ 2uy0]], [[ 1zp8]], [[ 1xl2]], [[ 1xl5]], [[ 1zpa]], [[ 1yt9]], [[ 2a4f ]], [[ 1upj]], [[ 2upj]], [[ 7upj]], [[ 1hxb]], [[ 1hih]], [[ 1hvr]], [[ 1hef]], [[ 1heg]], [[ 4phv]], [[ 1w5w]], [[ 1w5x]], [[ 1w5v]], [[ 1w5y]], [[ 1t7k]], [[ 1npa]], [[ 1npv]], [[ 1npw]], [[ 1eby]], [[ 1ec0]], [[ 1g2k]], [[ 1c6x]], [[ 1c6y]], [[ 1c6z]], [[ 1hwr]], [[ 2bpv]], [[ 2bpw]], [[ 2bpx]], [[ 2bpy]], [[ 2bpz]], [[ 1ody]], [[ 1hvh]], [[ 3tlh]], [[ 1hxw]] - HIV1-PR + inhibitor<br />
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[[2zye]] - HIV1-PR + inhibitor - neutron<br />
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3aid]], [[ 1ytg]], [[ 1yth]], [[ 2nxd]], [[ 2nxl]], [[ 2nxm]], [[ 2fns]], [[ 2fnt]], [[ 1zj7]], [[ 1zlf]], [[ 1zpk]], [[ 1zsf]], [[ 1zsr]], [[
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1cpi]], [[ 1m0b]], [[ 1iiq]], [[ 1fqx]], [[ 1a30]] - HIV1-PR + polypeptide derivative
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1sp5]] - HIV1-PR + autoproteolytic peptide
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===HIV-1 (mutant) complexes===
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[[3nu3]], [[ 3nu4]], [[ 3nu5]], [[ 3nu6]], [[ 3nu9]], [[ 3nuj]], [[ 3nuo]], [[ 2qhc]], [[ 2qak]], [[ 2pym]], [[ 2pyn]], [[ 2q63]], [[ 2q64]], [[ 2fxd]], [[ 2fxe]], [[ 2fgu]], [[ 2fgv]], [[ 1sdt]], [[ 1sdu]], [[ 1sdv]], [[ 1d4y]], [[ 1d4s]] - HIV1-PR (mutant) + antiviral drug<br />
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[[2aid]], [[ 1hpo]], [[ 1tcx]], [[ 1gnm]], [[ 1gnn]], [[ 1gno]], [[ 1kzk]], [[ 3ok9]], [[ 3i8w]], [[ 3i7e]], [[ 3bxr]], [[ 3bxs]], [[ 2hc0]], [[ 2psu]], [[ 2psv]], [[ 2fle]], [[ 2f3k]], [[ 2ien]], [[ 2fdd]], [[ 2fde]], [[ 1t7i]], [[ 1t3r]], [[ 1mrw]], [[ 1mrx]], [[ 1msm]], [[ 1msn]], [[ 1bv9]] - HIV1-PR (mutant) + inhibitor<br />
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[[2p3b]] - HIV1-PR subtype B (mutant) + inhibitor<br />
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[[2p3c]] - HIV1-PR subtype F (mutant) + inhibitor<br />
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[[1zbg]], [[ 1z8c]], [[ 2az9]], [[ 2azc]], [[ 2a1e]], [[ 1lzq]], [[ 1d4k]], [[ 1d4l]], [[ 1a8k]], [[ 1a94]], [[ 1axa]] - HIV1-PR (mutant) + polypeptide derivative<br />
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[[1ztz]] - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane
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===HIV-1 (drug-resistant mutant) complexes===
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[[3el4]], [[ 3el9]], [[ 3em3]], [[ 3em4]], [[ 3em6]], [[ 3ggt]], [[ 3ggu]], [[ 1t7j]], [[ 1rv7]], [[ 1n49]], [[ 1fb7]] - HIV1-PR (drug-resistant mutant) + antiviral drug<br />
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[[1izh]], [[ 1izi]], [[ 1fb7]] - HIV1-PR (drug-resistant mutant) + inhibitor<br />
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[[2p3a]] - HIV1-PR subtype B (drug-resistant mutant) + inhibitor<br />
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2p3d]] - HIV1-PR subtype F (drug-resistant mutant) + inhibitor<br />
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===HIV-2===
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[[1jld]] - HIV2-PR<br />
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[[1hii]] - HIV2-PR + inhibitor<br />
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[[5upj]], [[ 6upj]], [[ 3upj]], [[ 4upj]] - HIV2-PR (mutant) + inhibitor<br />
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[[1ida]], [[ 1idb]], [[ 2mip]] - HIV2-PR + polypeptide derivative
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===Feline Immunodeficiency Virus-PR===
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[[2hah]] - FIV-PR residues 39-154 (mutant) + inhibitor<br />
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[[5fiv]], [[ 6fiv]], [[ 1b11]] - FIV-PR + inhibitor<br />
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===Simian Immunodeficiency Virus-PR]]]
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[[2sam]] - SIV-PR + inhibitor<br />
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[[1az5]] - SIV-PR (mutant)
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===XMRV-PR===
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[[3nr6]] – XMRV-PR P14<br />
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[[3p1g]] – XMRV-PR RNase H domain (mutant)

Revision as of 10:42, 4 April 2011

Image:1odw.png
Crystal Structure of HIV-1 protease 1odw

Template:STRUCTURE 1odw

Virus proteases include HIV protease, XMRV protease, retropepsin. HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa.


Contents



3D Structures of Virus proteases

HIV-1

3ixo - HIV1-PR subtype A
1odx, 2hb2, 2hb4, 2pc0 - HIV1-PR (mutant)
1rpi, 1rq9, 1tw7 - HIV1-PR (drug-resistant mutant)
1odw, 3kf1 - HIV1-PR

HIV-1 complexes

1hsg, 1hsh, 1hsi, 3oxc, 3ekv, 3ekx, 3eky, 3el1, 1ohr - HIV1-PR + antiviral drug
1aid, 1qbr, 1qbs, 1qbt, 1qbu, 3mxe, 3m9f , 3kf0, 3kf1, 3kfn, 3kfp, 3kfr, 3kfs, 2wkz, 2wl0, 3gga, 3ggv, 3ggx, 2uxz, 2uy0, 1zp8, 1xl2, 1xl5, 1zpa, 1yt9, 2a4f , 1upj, 2upj, 7upj, 1hxb, 1hih, 1hvr, 1hef, 1heg, 4phv, 1w5w, 1w5x, 1w5v, 1w5y, 1t7k, 1npa, 1npv, 1npw, 1eby, 1ec0, 1g2k, 1c6x, 1c6y, 1c6z, 1hwr, 2bpv, 2bpw, 2bpx, 2bpy, 2bpz, 1ody, 1hvh, 3tlh, 1hxw - HIV1-PR + inhibitor
2zye - HIV1-PR + inhibitor - neutron
3aid]], 1ytg, 1yth, 2nxd, 2nxl, 2nxm, 2fns, 2fnt, 1zj7, 1zlf, 1zpk, 1zsf, 1zsr, [[ 1cpi]], 1m0b, 1iiq, 1fqx, 1a30 - HIV1-PR + polypeptide derivative 1sp5]] - HIV1-PR + autoproteolytic peptide

HIV-1 (mutant) complexes

3nu3, 3nu4, 3nu5, 3nu6, 3nu9, 3nuj, 3nuo, 2qhc, 2qak, 2pym, 2pyn, 2q63, 2q64, 2fxd, 2fxe, 2fgu, 2fgv, 1sdt, 1sdu, 1sdv, 1d4y, 1d4s - HIV1-PR (mutant) + antiviral drug
2aid, 1hpo, 1tcx, 1gnm, 1gnn, 1gno, 1kzk, 3ok9, 3i8w, 3i7e, 3bxr, 3bxs, 2hc0, 2psu, 2psv, 2fle, 2f3k, 2ien, 2fdd, 2fde, 1t7i, 1t3r, 1mrw, 1mrx, 1msm, 1msn, 1bv9 - HIV1-PR (mutant) + inhibitor
2p3b - HIV1-PR subtype B (mutant) + inhibitor
2p3c - HIV1-PR subtype F (mutant) + inhibitor
1zbg, 1z8c, 2az9, 2azc, 2a1e, 1lzq, 1d4k, 1d4l, 1a8k, 1a94, 1axa - HIV1-PR (mutant) + polypeptide derivative
1ztz - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane

HIV-1 (drug-resistant mutant) complexes

3el4, 3el9, 3em3, 3em4, 3em6, 3ggt, 3ggu, 1t7j, 1rv7, 1n49, 1fb7 - HIV1-PR (drug-resistant mutant) + antiviral drug
1izh, 1izi, 1fb7 - HIV1-PR (drug-resistant mutant) + inhibitor
2p3a - HIV1-PR subtype B (drug-resistant mutant) + inhibitor
2p3d]] - HIV1-PR subtype F (drug-resistant mutant) + inhibitor

HIV-2

1jld - HIV2-PR
1hii - HIV2-PR + inhibitor
5upj, 6upj, 3upj, 4upj - HIV2-PR (mutant) + inhibitor
1ida, 1idb, 2mip - HIV2-PR + polypeptide derivative

Feline Immunodeficiency Virus-PR

2hah - FIV-PR residues 39-154 (mutant) + inhibitor
5fiv, 6fiv, 1b11 - FIV-PR + inhibitor

===Simian Immunodeficiency Virus-PR]]]

2sam - SIV-PR + inhibitor
1az5 - SIV-PR (mutant)

XMRV-PR

3nr6 – XMRV-PR P14
3p1g – XMRV-PR RNase H domain (mutant)

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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