This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3nds

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3nds" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3nds.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3nds", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3nds| PDB=3nds | SCENE= }}
{{STRUCTURE_3nds| PDB=3nds | SCENE= }}
- 
===Crystal structure of engineered Naja Nigricollis toxin alpha===
===Crystal structure of engineered Naja Nigricollis toxin alpha===
 +
{{ABSTRACT_PUBMED_20804768}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/NXS1_NAJPA NXS1_NAJPA]] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.<ref>PMID:9305882</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20804768}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 20804768 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_20804768}}
+
==About this Structure==
==About this Structure==
Line 22: Line 10:
==Reference==
==Reference==
-
<ref group="xtra">PMID:20804768</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020804768</ref><references group="xtra"/><references/>
[[Category: Drevet, P.]]
[[Category: Drevet, P.]]
[[Category: Gallopin, M.]]
[[Category: Gallopin, M.]]
Line 28: Line 16:
[[Category: Stura, E A.]]
[[Category: Stura, E A.]]
[[Category: Vandame, M.]]
[[Category: Vandame, M.]]
 +
[[Category: Disulfide pairing]]
 +
[[Category: Folding intermediate]]
 +
[[Category: Snake toxin]]
 +
[[Category: Three finger toxin fold]]
 +
[[Category: Toxin]]
 +
[[Category: Venom]]

Revision as of 11:57, 24 April 2013

Template:STRUCTURE 3nds

Contents

Crystal structure of engineered Naja Nigricollis toxin alpha

Template:ABSTRACT PUBMED 20804768

Function

[NXS1_NAJPA] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.[1]

About this Structure

3nds is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Gross G, Gallopin M, Vandame M, Couprie J, Stura E, Zinn-Justin S, Drevet P. Conformational exchange is critical for the productivity of an oxidative folding intermediate with buried free cysteines. J Mol Biol. 2010 Oct 22;403(2):299-312. Epub 2010 Sep 8. PMID:20804768 doi:10.1016/j.jmb.2010.07.048
  1. ↑ Servent D, Winckler-Dietrich V, Hu HY, Kessler P, Drevet P, Bertrand D, Menez A. Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal alpha7 nicotinic receptor. J Biol Chem. 1997 Sep 26;272(39):24279-86. PMID:9305882

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nds"
Personal tools