TonB

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===BtuB-TonB Complex===
===BtuB-TonB Complex===
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TonB complexes with BtuB in order to aid the transport of nutrients across the outer membrane by incorporating the proton-motive force into the outer membrane.<ref name='Shultis'>PMID: 16741124</ref>
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TonB complexes with BtuB in order to aid the transport of nutrients such as cobalamins<ref name="Cadieux">PMID 11029413</ref> across the outer membrane by incorporating the proton-motive force into the outer membrane.<ref name='Shultis'>PMID: 16741124</ref> TonB attaches to BtuB on the periplasmic side of the 614 amino acid BtuB protein <ref name='Shultis'> PMID: 16741124</ref>
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The BtuB-[[TonB]] complex is involved in the uptake of essential nutrients from outside the cell across the outer membrane.
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{{STRUCTURE_2gsk | PDB=2gsk | SCENE= BtuB-TonB_Complex/Btubtonbcomplex/1 }}
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TonB attaches to BtuB on the periplasmic side of the 614 amino acid BtuB protein <ref name='Shultis'> PMID: 16741124</ref>==Regulation==
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===Interaction with TonB Box===
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{{STRUCTURE_2gsk | PDB=2gsk | SCENE= BtuB-TonB_Complex/Btubtonbcomplex/1 }}
 
== References==
== References==
<references/>
<references/>

Revision as of 09:22, 25 April 2011

Template:STRUCTURE 1xx3

TonB is involved in the uptake of iron as a component of the TonB/ExbB/ExbD complex of the Ton system.

Contents

Structure

TonB and ExbD bind to ExbB in a protein complex that prevents the degradation of the TonB protein. TonB and ExbD are anchored to the cytoplasmic membrane via their N-terminal hydrophobic sequences, with the rest of the protein complex extending into the periplasmic space, allowing for interaction with outer membrane proteins.[1]


Function

The activity of TonB is determined by the presence of ExbB and ExbD. [1]

BtuB-TonB Complex

TonB complexes with BtuB in order to aid the transport of nutrients such as cobalamins[2] across the outer membrane by incorporating the proton-motive force into the outer membrane.[3] TonB attaches to BtuB on the periplasmic side of the 614 amino acid BtuB protein [3]

Template:STRUCTURE 2gsk

Interaction with TonB Box

References

  1. ↑ 1.0 1.1 Kampfenkel K, Braun V. Topology of the ExbB protein in the cytoplasmic membrane of Escherichia coli. J Biol Chem. 1993 Mar 15;268(8):6050-7. PMID:8449962
  2. ↑ Cadieux N, Bradbeer C, Kadner RJ. Sequence changes in the ton box region of BtuB affect its transport activities and interaction with TonB protein. J Bacteriol. 2000 Nov;182(21):5954-61. PMID:11029413
  3. ↑ 3.0 3.1 Shultis DD, Purdy MD, Banchs CN, Wiener MC. Outer membrane active transport: structure of the BtuB:TonB complex. Science. 2006 Jun 2;312(5778):1396-9. PMID:16741124 doi:312/5778/1396

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Laura McCauley

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