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Aldehyde dehydrogenase
From Proteopedia
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[[1ag8]] – bALDH NAD binding domain - bovine | [[1ag8]] – bALDH NAD binding domain - bovine | ||
| - | Binary complex | + | ''Binary complex'' |
[[3inj]], [[3inl]] - hALDH2 residues 18-517 + agonist<BR /> | [[3inj]], [[3inl]] - hALDH2 residues 18-517 + agonist<BR /> | ||
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[[1a4z]] – bALDH2 NAD-binding domain + NAD<BR /> | [[1a4z]] – bALDH2 NAD-binding domain + NAD<BR /> | ||
| - | Ternary complex | + | ''Ternary complex'' |
[[1o01]] - hALDH2 residues 18-517 + NADH + aldehyde | [[1o01]] - hALDH2 residues 18-517 + NADH + aldehyde | ||
| Line 40: | Line 40: | ||
[[2w8n]], [[2w8o]], [[2w8r]] – Succinate–semi-hALDH family 5<BR /> | [[2w8n]], [[2w8o]], [[2w8r]] – Succinate–semi-hALDH family 5<BR /> | ||
[[2w8p]] - Succinate–semi-hALDH family 5 (mutant) <BR /> | [[2w8p]] - Succinate–semi-hALDH family 5 (mutant) <BR /> | ||
| - | [[3r31]] – Betaine-ALDH – Agrobacterium tumefaciens<BR /> | + | [[3r31]] – Betaine-ALDH – ''Agrobacterium tumefaciens''<BR /> |
| - | [[3ed6]] - Betaine-SaALDH – Staphylococcus aureus<BR /> | + | [[3ed6]] - Betaine-SaALDH – ''Staphylococcus aureus''<BR /> |
[[1a4s]] - Betaine-cALDH - cod<BR /> | [[1a4s]] - Betaine-cALDH - cod<BR /> | ||
[[3llg]] – Aspartate-semi-MtALDH<BR /> | [[3llg]] – Aspartate-semi-MtALDH<BR /> | ||
[[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR /> | [[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR /> | ||
[[2nac]] – Formate-PsALDH<BR /> | [[2nac]] – Formate-PsALDH<BR /> | ||
| - | [[3i44]] – ALDH – Bartonella henselae<BR /> | + | [[3i44]] – ALDH – ''Bartonella henselae''<BR /> |
| - | [[3ek1]] – ALDH – Brucella melitensis | + | [[3ek1]] – ALDH – ''Brucella melitensis'' |
| - | Binary complexes | + | ''Binary complexes'' |
[[2w8q]] - Succinate–semi-hALDH family 5 + succinic acid<BR /> | [[2w8q]] - Succinate–semi-hALDH family 5 + succinic acid<BR /> | ||
| Line 56: | Line 56: | ||
[[2j6l]] – Aminoadipate-semi-hALDH family 7 + NAD<BR /> | [[2j6l]] – Aminoadipate-semi-hALDH family 7 + NAD<BR /> | ||
[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR /> | [[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR /> | ||
| - | [[2nad]] - Formate-PsALDH + NAD – Pseudomonas<BR /> | + | [[2nad]] - Formate-PsALDH + NAD – ''Pseudomonas''<BR /> |
[[1bi9]] – Retinal-rALDH2 + NAD<BR /> | [[1bi9]] – Retinal-rALDH2 + NAD<BR /> | ||
| - | [[3l4p]], [[1sij]] – ALDH + AsO3 – Desulfovibrio gigas | + | [[3l4p]], [[1sij]] – ALDH + AsO3 – ''Desulfovibrio gigas'' |
| - | Ternary complexes | + | ''Ternary complexes'' |
| - | [[2gsd]] – Formate-ALDH + NAD + azide – Moraxella<BR /> | + | [[2gsd]] – Formate-ALDH + NAD + azide – ''Moraxella''<BR /> |
[[1nvm]] – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD<BR /> | [[1nvm]] – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD<BR /> | ||
| - | [[1llu]] - PaALDH + NAD + alcohol – Pseudomonas aeruginosa | + | [[1llu]] - PaALDH + NAD + alcohol – ''Pseudomonas aeruginosa'' |
===NAD-dependent glyceraldehydes-3-phosphate dehydrogenase=== | ===NAD-dependent glyceraldehydes-3-phosphate dehydrogenase=== | ||
| - | [[1vsu]] – CpGAPDH – Cryptosporidium parvum<BR /> | + | [[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<BR /> |
| - | [[1ywg]] – PfGAPDH – Plasmodium falciparum<BR /> | + | [[1ywg]] – PfGAPDH – ''Plasmodium falciparum''<BR /> |
| - | [[3cmc]] - GAPDH – Bacillus stearothermophilus<BR /> | + | [[3cmc]] - GAPDH – ''Bacillus stearothermophilus''<BR /> |
| - | [[2ep7]] – GAPDH – Aquifex aeolicus<BR /> | + | [[2ep7]] – GAPDH – ''Aquifex aeolicus''<BR /> |
| - | [[2i5p]] – GAPDH – Kluyveromyces marxianus<BR /> | + | [[2i5p]] – GAPDH – ''Kluyveromyces marxianus''<BR /> |
| - | [[1obf]] – GAPDH – Achromobacter xylosoxidans<BR /> | + | [[1obf]] – GAPDH – ''Achromobacter xylosoxidans''<BR /> |
| - | [[1crw]] – PvGAPDH – Palinurus versicolor<BR /> | + | [[1crw]] – PvGAPDH – ''Palinurus versicolor''<BR /> |
| - | [[1b7g]] – GAPDH – Sulfolobus solfataricus<BR /> | + | [[1b7g]] – GAPDH – ''Sulfolobus solfataricus''<BR /> |
| - | [[2gd1]] – GsGAPDH – Geobacillus stearothermophilus<BR /> | + | [[2gd1]] – GsGAPDH – ''Geobacillus stearothermophilus''<BR /> |
| - | [[3e6a]] – OsGAPDH – Oryza sativa<BR /> | + | [[3e6a]] – OsGAPDH – ''Oryza sativa''<BR /> |
[[4gpd]], [[1gpd]] – GAPDH – lobster<BR /> | [[4gpd]], [[1gpd]] – GAPDH – lobster<BR /> | ||
[[3l6o]], [[3lc7]] – SaGAPDH<BR /> | [[3l6o]], [[3lc7]] – SaGAPDH<BR /> | ||
| - | [[1dc3]], [[1dc5]], [[1s7c]] – EcGAPDH - Escherichia coli | + | [[1dc3]], [[1dc5]], [[1s7c]] – EcGAPDH - ''Escherichia coli'' |
''GAPDH binary complex'' | ''GAPDH binary complex'' | ||
[[1k3t]] - TcGAPDH + inhibitor<BR /> | [[1k3t]] - TcGAPDH + inhibitor<BR /> | ||
| - | [[3hja]] - GAPDH + NAD – Borellia burgdorferi<BR /> | + | [[3hja]] - GAPDH + NAD – ''Borellia burgdorferi''<BR /> |
[[1vsv]], [[3cps]] - CpGAPDH + NAD<BR /> | [[1vsv]], [[3cps]] - CpGAPDH + NAD<BR /> | ||
[[2vyn]], [[2vyv]] - rGAPDH residues 102-432 + EcGAPDH + NAD<BR /> | [[2vyn]], [[2vyv]] - rGAPDH residues 102-432 + EcGAPDH + NAD<BR /> | ||
| Line 93: | Line 93: | ||
[[1dss]], [[1szj]] - PvGAPDH NAD-binding and catalytic domains+ NAD<BR /> | [[1dss]], [[1szj]] - PvGAPDH NAD-binding and catalytic domains+ NAD<BR /> | ||
[[1ihy]] – PvGAPDH + ADP-ribose<BR /> | [[1ihy]] – PvGAPDH + ADP-ribose<BR /> | ||
| - | [[1gyq]], [[1gyp]] - LmGAPDH + NAD derivative – Leishmania mexicana<BR /> | + | [[1gyq]], [[1gyp]] - LmGAPDH + NAD derivative – ''Leishmania mexicana''<BR /> |
[[1i32]], [[1i33]] – LmGAPDH + inhibitor<BR /> | [[1i32]], [[1i33]] – LmGAPDH + inhibitor<BR /> | ||
[[1a7k]] – LmGAPDH + NAD<BR /> | [[1a7k]] – LmGAPDH + NAD<BR /> | ||
| - | [[1cer]], [[2g82]] - GAPDH + NAD – Thermus aquaticus<BR /> | + | [[1cer]], [[2g82]] - GAPDH + NAD – ''Thermus aquaticus''<BR /> |
[[1gd1]] - GsGAPDH + NAD<BR /> | [[1gd1]] - GsGAPDH + NAD<BR /> | ||
[[1npt]], [[1nq5]], [[1dbv]], [[2dbv]], [[3dbv]], [[4dbv]] - GsGAPDH (mutant) + NAD<BR /> | [[1npt]], [[1nq5]], [[1dbv]], [[2dbv]], [[3dbv]], [[4dbv]] - GsGAPDH (mutant) + NAD<BR /> | ||
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''GAPDH ternary complex'' | ''GAPDH ternary complex'' | ||
| - | [[3id5]], [[3dmt]], [[1ml3]] – TcGAPDH + NAD + inhibitor – Trypanosoma cruzi<BR /> | + | [[3id5]], [[3dmt]], [[1ml3]] – TcGAPDH + NAD + inhibitor – ''Trypanosoma cruzi''<BR /> |
[[1qxs]] - TcGAPDH + NAD + G3P analog<BR /> | [[1qxs]] - TcGAPDH + NAD + G3P analog<BR /> | ||
[[3cif]] - CpGAPDH + NAD + G3P<BR /> | [[3cif]] - CpGAPDH + NAD + G3P<BR /> | ||
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===NADP-dependent specific aldehydes ALDH=== | ===NADP-dependent specific aldehydes ALDH=== | ||
| - | [[3k2w]] - Betaine-ALDH – Pseudoalteromonas atlantica<BR /> | + | [[3k2w]] - Betaine-ALDH – ''Pseudoalteromonas atlantica''<BR /> |
[[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR /> | [[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR /> | ||
[[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal | [[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal | ||
| - | Binary complexes | + | ''Binary complexes'' |
[[2wox]], [[2wme]] - Betaine-PaALDH + NADP<BR /> | [[2wox]], [[2wme]] - Betaine-PaALDH + NADP<BR /> | ||
| - | [[3lv1]] – Benzaldehyde-PpALDH3 + NADP – Pseudomonas putida<BR /> | + | [[3lv1]] – Benzaldehyde-PpALDH3 + NADP – ''Pseudomonas putida''<BR /> |
[[2ilu]] - Lactaldehyde-EcALDH + NADP<BR /> | [[2ilu]] - Lactaldehyde-EcALDH + NADP<BR /> | ||
[[2o2q]], [[2o2r]] - Formyltetrahydrofolate-rALDH C-terminal + NADP<BR /> | [[2o2q]], [[2o2r]] - Formyltetrahydrofolate-rALDH C-terminal + NADP<BR /> | ||
| - | [[3b4w]] - MtALDH + NADP – Mycobacterium tuberculosis<BR /> | + | [[3b4w]] - MtALDH + NADP – ''Mycobacterium tuberculosis''<BR /> |
| - | [[1eyy]], [[1ez0]] – ALDH + NADP – Vibrio harveyi | + | [[1eyy]], [[1ez0]] – ALDH + NADP – ''Vibrio harveyi'' |
| - | Ternary complexes | + | ''Ternary complexes'' |
[[3lns]] - Benzaldehyde-PpALDH3 + NADP + benzoate<BR /> | [[3lns]] - Benzaldehyde-PpALDH3 + NADP + benzoate<BR /> | ||
[[2imp]] - Lactaldehyde-EcALDH + NADH + lactate<BR /> | [[2imp]] - Lactaldehyde-EcALDH + NADH + lactate<BR /> | ||
| - | [[2vro]] – ALDH + NADP + alcohol – Burkholderia xenovorans | + | [[2vro]] – ALDH + NADP + alcohol – ''Burkholderia xenovorans'' |
===NADP-dependent glyceraldehydes-3-phosphate dehydrogenase=== | ===NADP-dependent glyceraldehydes-3-phosphate dehydrogenase=== | ||
| - | [[1euh]] - SmGAPDH – Streptococcus mutans<BR /> | + | [[1euh]] - SmGAPDH – ''Streptococcus mutans''<BR /> |
[[1qi6]] - SmGAPDH (mutant) | [[1qi6]] - SmGAPDH (mutant) | ||
| - | GAPDH binary complex | + | ''GAPDH binary complex'' |
[[2ehu]] - SmGAPDH + NADP<BR /> | [[2ehu]] - SmGAPDH + NADP<BR /> | ||
| - | [[2yyy]] – GAPDH + NADP – Methanocaldococcus jannaschii<BR /> | + | [[2yyy]] – GAPDH + NADP – ''Methanocaldococcus jannaschii''<BR /> |
[[2pkq]] - spGAPDH subunit A, B + NADP – spinach<BR /> | [[2pkq]] - spGAPDH subunit A, B + NADP – spinach<BR /> | ||
[[2pkr]], [[1rm4]], [[1jn0]] - spGAPDH subunit A + NADP<BR /> | [[2pkr]], [[1rm4]], [[1jn0]] - spGAPDH subunit A + NADP<BR /> | ||
[[1rm3]], [[1rm5]] - spGAPDH subunit A (mutant) + NADP<BR /> | [[1rm3]], [[1rm5]] - spGAPDH subunit A (mutant) + NADP<BR /> | ||
| - | [[2czc]] – GAPDH + NADP – Pyrococcus horikoshii | + | [[2czc]] – GAPDH + NADP – ''Pyrococcus horikoshii'' |
| - | GAPDH ternary complex | + | ''GAPDH ternary complex'' |
[[2esd]], [[1qi1]] – SmGAPDH (mutant) + NADP + G3P<BR /> | [[2esd]], [[1qi1]] – SmGAPDH (mutant) + NADP + G3P<BR /> | ||
Revision as of 11:07, 27 April 2011
Aldehyde dehydrogenase (ALDH) converts aldehydes to carboxylic acids while reducing NAD+ to NADH. In mammals there are 3 classes of ALDH and each contain constitutive and inducible forms. Class 1 is cytosolic; class 2 mitochondrial; class 3 found in tumors, stomach and cornea). ALDH family 7 member A1 is known as antiquitin and functions in the detoxification of aldehydes. Glyceraldehyde-3-phophate (G3P)-ALDH is called GAPDH.
3D Structures of Aldehyde dehydrogenase
ALDH class 1
3fx4 – ALDH1 + NADP + inhibitor – pig
1bxs – ALDH1 - sheep
ALDH class 2
3n80, 1o05 – hALDH2 residues 18-517- human
3n81, 2onn, 2ono, 1zum – hALDH2 residues 18-517 (mutant)
1ag8 – bALDH NAD binding domain - bovine
Binary complex
3inj, 3inl - hALDH2 residues 18-517 + agonist
2vle - hALDH2 residues 24-517 + daidzin
1nzx, 1nzz, 1o00, 1o02, 1cw3 - hALDH2 residues 18-517 + NAD
3n82, 3n83, 2onm, 2onp, 1nzw, 1o04 – hALDH2 residues 18-517 (mutant) + NADH
1a4z – bALDH2 NAD-binding domain + NAD
Ternary complex
1o01 - hALDH2 residues 18-517 + NADH + aldehyde
ALDH class 3
1ad3 – rALDH - rat
NAD-dependent specific aldehydes ALDH
2w8n, 2w8o, 2w8r – Succinate–semi-hALDH family 5
2w8p - Succinate–semi-hALDH family 5 (mutant)
3r31 – Betaine-ALDH – Agrobacterium tumefaciens
3ed6 - Betaine-SaALDH – Staphylococcus aureus
1a4s - Betaine-cALDH - cod
3llg – Aspartate-semi-MtALDH
2cq8 - Formyltetrahydrofolate-hALDH PP-binding domain - NMR
2nac – Formate-PsALDH
3i44 – ALDH – Bartonella henselae
3ek1 – ALDH – Brucella melitensis
Binary complexes
2w8q - Succinate–semi-hALDH family 5 + succinic acid
3fg0 - Betaine-SaALDH + NAD
1bpw - Betaine-cALDH + NAD
2j6l – Aminoadipate-semi-hALDH family 7 + NAD
2cfi - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin
2nad - Formate-PsALDH + NAD – Pseudomonas
1bi9 – Retinal-rALDH2 + NAD
3l4p, 1sij – ALDH + AsO3 – Desulfovibrio gigas
Ternary complexes
2gsd – Formate-ALDH + NAD + azide – Moraxella
1nvm – Acetaldehyde-PsALDH + 4-hydroxy-oxovalerate aldolase + NAD
1llu - PaALDH + NAD + alcohol – Pseudomonas aeruginosa
NAD-dependent glyceraldehydes-3-phosphate dehydrogenase
1vsu – CpGAPDH – Cryptosporidium parvum
1ywg – PfGAPDH – Plasmodium falciparum
3cmc - GAPDH – Bacillus stearothermophilus
2ep7 – GAPDH – Aquifex aeolicus
2i5p – GAPDH – Kluyveromyces marxianus
1obf – GAPDH – Achromobacter xylosoxidans
1crw – PvGAPDH – Palinurus versicolor
1b7g – GAPDH – Sulfolobus solfataricus
2gd1 – GsGAPDH – Geobacillus stearothermophilus
3e6a – OsGAPDH – Oryza sativa
4gpd, 1gpd – GAPDH – lobster
3l6o, 3lc7 – SaGAPDH
1dc3, 1dc5, 1s7c – EcGAPDH - Escherichia coli
GAPDH binary complex
1k3t - TcGAPDH + inhibitor
3hja - GAPDH + NAD – Borellia burgdorferi
1vsv, 3cps - CpGAPDH + NAD
2vyn, 2vyv - rGAPDH residues 102-432 + EcGAPDH + NAD
2b4r, 2b4t – PfGAPDH (mutant) + NAD
1j0x – GAPDH + NAD – rabbit
1ihx – PvGAPDH + NAD
1dss, 1szj - PvGAPDH NAD-binding and catalytic domains+ NAD
1ihy – PvGAPDH + ADP-ribose
1gyq, 1gyp - LmGAPDH + NAD derivative – Leishmania mexicana
1i32, 1i33 – LmGAPDH + inhibitor
1a7k – LmGAPDH + NAD
1cer, 2g82 - GAPDH + NAD – Thermus aquaticus
1gd1 - GsGAPDH + NAD
1npt, 1nq5, 1dbv, 2dbv, 3dbv, 4dbv - GsGAPDH (mutant) + NAD
3e5r – OsGAPDH + NAD
3k73, 3lvf – SaGAPDH + NAD
3lc2 - SaGAPDH + G3P
3k9q, 3ksd, 3lc1, 3hq4 - SaGAPDH (mutant) + NAD
3gpd, 1u8f, 1znq – hGAPDH + NAD
1gad, 1dc6 - EcGAPDH + NAD
1gae - EcGAPDH (mutant) + NAD
1dc4 – EcGAPDH + G3P
GAPDH ternary complex
3id5, 3dmt, 1ml3 – TcGAPDH + NAD + inhibitor – Trypanosoma cruzi
1qxs - TcGAPDH + NAD + G3P analog
3cif - CpGAPDH + NAD + G3P
1nqa, 1nqo - GsGAPDH (mutant) + NAD + G3P
3ksz, 3kv3, 3l4s - SaGAPDH (mutant) + NAD + G3P
NADP-dependent specific aldehydes ALDH
3k2w - Betaine-ALDH – Pseudoalteromonas atlantica
2hg2, 2opx – Lactaldehyde-EcALDH
2o2p – Formyltetrahydrofolate-rALDH C-terminal
Binary complexes
2wox, 2wme - Betaine-PaALDH + NADP
3lv1 – Benzaldehyde-PpALDH3 + NADP – Pseudomonas putida
2ilu - Lactaldehyde-EcALDH + NADP
2o2q, 2o2r - Formyltetrahydrofolate-rALDH C-terminal + NADP
3b4w - MtALDH + NADP – Mycobacterium tuberculosis
1eyy, 1ez0 – ALDH + NADP – Vibrio harveyi
Ternary complexes
3lns - Benzaldehyde-PpALDH3 + NADP + benzoate
2imp - Lactaldehyde-EcALDH + NADH + lactate
2vro – ALDH + NADP + alcohol – Burkholderia xenovorans
NADP-dependent glyceraldehydes-3-phosphate dehydrogenase
1euh - SmGAPDH – Streptococcus mutans
1qi6 - SmGAPDH (mutant)
GAPDH binary complex
2ehu - SmGAPDH + NADP
2yyy – GAPDH + NADP – Methanocaldococcus jannaschii
2pkq - spGAPDH subunit A, B + NADP – spinach
2pkr, 1rm4, 1jn0 - spGAPDH subunit A + NADP
1rm3, 1rm5 - spGAPDH subunit A (mutant) + NADP
2czc – GAPDH + NADP – Pyrococcus horikoshii
GAPDH ternary complex
2esd, 1qi1 – SmGAPDH (mutant) + NADP + G3P
Antiquitin
2jg7 – Antiquitin – Acanthopagrus schlegeli
