1zw0
From Proteopedia
(New page: 200px<br /><applet load="1zw0" size="350" color="white" frame="true" align="right" spinBox="true" caption="1zw0, resolution 1.80Å" /> '''Crystal structure of...) |
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==Overview== | ==Overview== | ||
| - | The plague-causing bacterium Yersinia pestis utilizes a contact-dependent | + | The plague-causing bacterium Yersinia pestis utilizes a contact-dependent (type III) secretion system (T3SS) to transport virulence factors from the bacterial cytosol directly into the interior of mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. The type III secretion apparatus is composed of 20-25 different Yersinia secretion (Ysc) proteins. We report here the structure of YscE, the smallest Ysc protein, which is a dimer in solution. The probable mode of oligomerization is discussed. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Yersinia pestis]] | [[Category: Yersinia pestis]] | ||
| - | [[Category: Austin, B | + | [[Category: Austin, B P.]] |
[[Category: Phan, J.]] | [[Category: Phan, J.]] | ||
| - | [[Category: Waugh, D | + | [[Category: Waugh, D S.]] |
[[Category: chaperone]] | [[Category: chaperone]] | ||
[[Category: export]] | [[Category: export]] | ||
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[[Category: yersinia]] | [[Category: yersinia]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:19:36 2008'' |
Revision as of 14:19, 21 February 2008
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Crystal structure of the Yersinia Type III Secretion protein YscE
Overview
The plague-causing bacterium Yersinia pestis utilizes a contact-dependent (type III) secretion system (T3SS) to transport virulence factors from the bacterial cytosol directly into the interior of mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. The type III secretion apparatus is composed of 20-25 different Yersinia secretion (Ysc) proteins. We report here the structure of YscE, the smallest Ysc protein, which is a dimer in solution. The probable mode of oligomerization is discussed.
About this Structure
1ZW0 is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.
Reference
Crystal structure of the Yersinia type III secretion protein YscE., Phan J, Austin BP, Waugh DS, Protein Sci. 2005 Oct;14(10):2759-63. PMID:16195558
Page seeded by OCA on Thu Feb 21 16:19:36 2008
