205d
From Proteopedia
(New page: 200px<br /><applet load="205d" size="350" color="white" frame="true" align="right" spinBox="true" caption="205d, resolution 2.640Å" /> '''STRUCTURE OF AN RNA...) |
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==Overview== | ==Overview== | ||
| - | The crystal structure of the RNA dodecamer 5'-GGACUUUGGUCC-3' has been | + | The crystal structure of the RNA dodecamer 5'-GGACUUUGGUCC-3' has been determined from X-ray diffraction data to 2.6 A resolution. This oligomer forms an asymmetric double helix in the crystal. Four consecutive non-Watson-Crick base-pairs are formed in the middle of the duplex including the first intrahelical U-U (or T-T) pairs observed in an oligonucleotide crystal structure. Two different conformations of U-U pairs are observed in the context of the surrounding sequence. One of these pairs is highly twisted, allowing a bound water to bridge across strands in the major groove. The crystal packing illustrates a new form of RNA helix-helix interaction. |
==About this Structure== | ==About this Structure== | ||
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Structure of an RNA double helix including uracil-uracil base pairs in an internal loop., Baeyens KJ, De Bondt HL, Holbrook SR, Nat Struct Biol. 1995 Jan;2(1):56-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7719854 7719854] | Structure of an RNA double helix including uracil-uracil base pairs in an internal loop., Baeyens KJ, De Bondt HL, Holbrook SR, Nat Struct Biol. 1995 Jan;2(1):56-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7719854 7719854] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Baeyens, K | + | [[Category: Baeyens, K J.]] |
| - | [[Category: Bondt, H | + | [[Category: Bondt, H L.De.]] |
| - | [[Category: Holbrook, S | + | [[Category: Holbrook, S R.]] |
[[Category: a-rna]] | [[Category: a-rna]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
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[[Category: mismatched]] | [[Category: mismatched]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:20:49 2008'' |
Revision as of 14:20, 21 February 2008
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STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP
Overview
The crystal structure of the RNA dodecamer 5'-GGACUUUGGUCC-3' has been determined from X-ray diffraction data to 2.6 A resolution. This oligomer forms an asymmetric double helix in the crystal. Four consecutive non-Watson-Crick base-pairs are formed in the middle of the duplex including the first intrahelical U-U (or T-T) pairs observed in an oligonucleotide crystal structure. Two different conformations of U-U pairs are observed in the context of the surrounding sequence. One of these pairs is highly twisted, allowing a bound water to bridge across strands in the major groove. The crystal packing illustrates a new form of RNA helix-helix interaction.
About this Structure
205D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of an RNA double helix including uracil-uracil base pairs in an internal loop., Baeyens KJ, De Bondt HL, Holbrook SR, Nat Struct Biol. 1995 Jan;2(1):56-62. PMID:7719854
Page seeded by OCA on Thu Feb 21 16:20:49 2008
