3pxj

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[[Image:3pxj.png|left|200px]]
 
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{{STRUCTURE_3pxj| PDB=3pxj | SCENE= }}
{{STRUCTURE_3pxj| PDB=3pxj | SCENE= }}
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===Tandem Ig repeats of Dlar===
===Tandem Ig repeats of Dlar===
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{{ABSTRACT_PUBMED_21402080}}
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==Function==
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[[http://www.uniprot.org/uniprot/LAR_DROME LAR_DROME]] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance.<ref>PMID:2554325</ref> <ref>PMID:8598047</ref>
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{{ABSTRACT_PUBMED_21402080}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021402080</ref><references group="xtra"/>
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<ref group="xtra">PMID:021402080</ref><references group="xtra"/><references/>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Biersmith, B H.]]
[[Category: Biersmith, B H.]]
[[Category: Bouyain, S.]]
[[Category: Bouyain, S.]]
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[[Category: Cell adhesion]]
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[[Category: Hydrolase]]
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[[Category: Ig domain]]
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[[Category: Receptor protein tyrosine phosphatase]]

Revision as of 08:06, 8 May 2013

Template:STRUCTURE 3pxj

Contents

Tandem Ig repeats of Dlar

Template:ABSTRACT PUBMED 21402080

Function

[LAR_DROME] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance.[1] [2]

About this Structure

3pxj is a 4 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

  • Biersmith BH, Hammel M, Geisbrecht ER, Bouyain S. The Immunoglobulin-like Domains 1 and 2 of the Protein Tyrosine Phosphatase LAR Adopt an Unusual Horseshoe-like Conformation. J Mol Biol. 2011 May 13;408(4):616-27. Epub 2011 Mar 21. PMID:21402080 doi:10.1016/j.jmb.2011.03.013
  1. ↑ Streuli M, Krueger NX, Tsai AY, Saito H. A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8698-702. PMID:2554325
  2. ↑ Krueger NX, Van Vactor D, Wan HI, Gelbart WM, Goodman CS, Saito H. The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila. Cell. 1996 Feb 23;84(4):611-22. PMID:8598047

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