3mo7
From Proteopedia
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{{STRUCTURE_3mo7| PDB=3mo7 | SCENE= }} | {{STRUCTURE_3mo7| PDB=3mo7 | SCENE= }} | ||
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===Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP=== | ===Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP=== | ||
| + | {{ABSTRACT_PUBMED_21417464}} | ||
| - | + | ==Disease== | |
| - | + | [[http://www.uniprot.org/uniprot/PYR5_HUMAN PYR5_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | |
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==About this Structure== | ==About this Structure== | ||
[[3mo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MO7 OCA]. | [[3mo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MO7 OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Phosphoribosyltransferase|Phosphoribosyltransferase]] | ||
| + | *[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021417464</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021417464</ref><references group="xtra"/><references/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Orotidine-5'-phosphate decarboxylase]] | [[Category: Orotidine-5'-phosphate decarboxylase]] | ||
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[[Category: Liu, Y.]] | [[Category: Liu, Y.]] | ||
[[Category: Pai, E F.]] | [[Category: Pai, E F.]] | ||
| + | [[Category: 2'-fluoro-6-iodo-ump]] | ||
| + | [[Category: Lyase]] | ||
| + | [[Category: Orotidine 5'-monophosphate decarboxylase]] | ||
| + | [[Category: Ump synthase]] | ||
Revision as of 09:57, 24 March 2013
Contents |
Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP
Template:ABSTRACT PUBMED 21417464
Disease
[PYR5_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.[1]
About this Structure
3mo7 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Lewis M, Meza-Avina ME, Wei L, Crandall IE, Bello AM, Poduch E, Liu Y, Paige CJ, Kain KC, Pai EF, Kotra LP. Novel Interactions of Fluorinated Nucleotide Derivatives Targeting Orotidine 5'-Monophosphate Decarboxylase. J Med Chem. 2011 Mar 21. PMID:21417464 doi:10.1021/jm101642g
