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3p7j
From Proteopedia
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{{STRUCTURE_3p7j| PDB=3p7j | SCENE= }} | {{STRUCTURE_3p7j| PDB=3p7j | SCENE= }} | ||
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===Drosophila HP1a chromo shadow domain=== | ===Drosophila HP1a chromo shadow domain=== | ||
| + | {{ABSTRACT_PUBMED_21472955}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/HP1_DROME HP1_DROME]] Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021472955</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021472955</ref><references group="xtra"/><references/> |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Chruszcz, M.]] | [[Category: Chruszcz, M.]] | ||
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[[Category: Kim, D.]] | [[Category: Kim, D.]] | ||
[[Category: Minor, W.]] | [[Category: Minor, W.]] | ||
| + | [[Category: Chromo shadow domain]] | ||
| + | [[Category: Epigenetic]] | ||
| + | [[Category: Gene silencing]] | ||
| + | [[Category: Heterochromatin protein 1]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 08:22, 2 May 2013
Contents |
Drosophila HP1a chromo shadow domain
Template:ABSTRACT PUBMED 21472955
Function
[HP1_DROME] Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
About this Structure
3p7j is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
- Mendez DL, Kim D, Chruszcz M, Stephens GE, Minor W, Khorasanizadeh S, Elgin SC. The HP1a Disordered C Terminus and Chromo Shadow Domain Cooperate to Select Target Peptide Partners. Chembiochem. 2011 May 2;12(7):1084-96. doi: 10.1002/cbic.201000598. Epub, 2011 Apr 5. PMID:21472955 doi:10.1002/cbic.201000598
