Adrenergic receptor
From Proteopedia
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| - | [[Image:B2ar Image3.png|left|200px|thumb|Crystal Structure of | + | [[Image:B2ar Image3.png|left|200px|thumb|Crystal Structure of β-2 Adrenergic Receptor, [[2rh1]]]] |
| - | {{STRUCTURE_2rh1| PDB=2rh1 | SIZE=300| SCENE=Beta-2_Adrenergic_Receptor/Opening/1 |right|CAPTION= | + | {{STRUCTURE_2rh1| PDB=2rh1 | SIZE=300| SCENE=Beta-2_Adrenergic_Receptor/Opening/1 |right|CAPTION=β-2 Adrenergic Receptor, [[2rh1]] }} |
| - | The [[Adrenergic receptor|adrenergic receptors]] are metabolic G protein-coupled receptors. They are the targets of catecholamines. The binding of an agonist to them causes a sympathetic response. The α-2 adrenergic receptor (A2AR) inhibits insulin or glucagons release. The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin. The β-2 adrenergic receptor (B2AR) triggers many relaxation reactions. The images at the left and at the right correspond to one representative Adrenergic receptor, ''i.e.'' the crystal structure of human | + | The [[Adrenergic receptor|adrenergic receptors]] are metabolic G protein-coupled receptors. They are the targets of catecholamines. The binding of an agonist to them causes a sympathetic response. The α-2 adrenergic receptor (A2AR) inhibits insulin or glucagons release. The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin. The β-2 adrenergic receptor (B2AR) triggers many relaxation reactions. The images at the left and at the right correspond to one representative Adrenergic receptor, ''i.e.'' the crystal structure of human β-2 adrenergic Receptor ([[2rh1]]). '''See also [[Beta-2 Adrenergic Receptor]].''' |
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== 3D Structures of Adrenergic receptor == | == 3D Structures of Adrenergic receptor == | ||
| - | === | + | ===α-2 adrenergic receptor=== |
| - | [[3kj6]], [[2r4r]], [[2r4s]] – | + | [[3kj6]], [[2r4r]], [[2r4s]] – hA2AR + FAB heavy+light chains<br /> |
[[1ho9]], [[1hod]] – hA2AR peptide (mutant) – NMR<br /> | [[1ho9]], [[1hod]] – hA2AR peptide (mutant) – NMR<br /> | ||
[[1hof]], [[1hll]] - hA2AR peptide – NMR<br /> | [[1hof]], [[1hll]] - hA2AR peptide – NMR<br /> | ||
| - | === | + | ===β-1 adrenergic receptor=== |
[[2y01]] – tB1AR fragment (mutant) – turkey<br /> | [[2y01]] – tB1AR fragment (mutant) – turkey<br /> | ||
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[[2y00]], [[2y02]], [[2y03]], [[2y04]], [[2vt4]] - tB1AR fragment (mutant) + agonist<br /> | [[2y00]], [[2y02]], [[2y03]], [[2y04]], [[2vt4]] - tB1AR fragment (mutant) + agonist<br /> | ||
| - | === | + | ===β-2 adrenergic receptor=== |
See also [[Beta-2 Adrenergic Receptor]]<br /> | See also [[Beta-2 Adrenergic Receptor]]<br /> | ||
[[3pds]] - hB2AR/T4 lysozyme - human<br /> | [[3pds]] - hB2AR/T4 lysozyme - human<br /> | ||
Revision as of 10:56, 12 May 2011
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| β-2 Adrenergic Receptor, 2rh1 | |||||||||
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| Ligands: | , , , , , , , | ||||||||
| Gene: | ADRB2, ADRB2R, B2AR / E (Enterobacteria phage T4) | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
The adrenergic receptors are metabolic G protein-coupled receptors. They are the targets of catecholamines. The binding of an agonist to them causes a sympathetic response. The α-2 adrenergic receptor (A2AR) inhibits insulin or glucagons release. The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin. The β-2 adrenergic receptor (B2AR) triggers many relaxation reactions. The images at the left and at the right correspond to one representative Adrenergic receptor, i.e. the crystal structure of human β-2 adrenergic Receptor (2rh1). See also Beta-2 Adrenergic Receptor.
Contents |
3D Structures of Adrenergic receptor
α-2 adrenergic receptor
3kj6, 2r4r, 2r4s – hA2AR + FAB heavy+light chains
1ho9, 1hod – hA2AR peptide (mutant) – NMR
1hof, 1hll - hA2AR peptide – NMR
β-1 adrenergic receptor
2y01 – tB1AR fragment (mutant) – turkey
1dep – tB1AR peptide - NMR
2y00, 2y02, 2y03, 2y04, 2vt4 - tB1AR fragment (mutant) + agonist
β-2 adrenergic receptor
See also Beta-2 Adrenergic Receptor
3pds - hB2AR/T4 lysozyme - human
3p0g – hB2AR/T4 lysozyme + cameloid antibody fragment
2rh1 - hB2AR/T4 lysozyme (mutant)
3d4s - hB2AR/T4 lysozyme (mutant) + cholesterol
3ny8, 3ny9, 3nya – hB2AR + agonist
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Wayne Decatur, Karsten Theis, Alexander Berchansky
