2ar6
From Proteopedia
(New page: 200px<br /><applet load="2ar6" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ar6, resolution 1.8Å" /> '''Pterocarpus angolensi...) |
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==Overview== | ==Overview== | ||
| - | The crystal structure of Pterocarpus angolensis lectin is determined in | + | The crystal structure of Pterocarpus angolensis lectin is determined in its ligand-free state, in complex with the fucosylated biantennary complex type decasaccharide NA2F, and in complex with a series of smaller oligosaccharide constituents of NA2F. These results together with thermodynamic binding data indicate that the complete oligosaccharide binding site of the lectin consists of five subsites allowing the specific recognition of the pentasaccharide GlcNAc beta(1-2)Man alpha(1-3)[GlcNAc beta(1-2)Man alpha(1-6)]Man. The mannose on the 1-6 arm occupies the monosaccharide binding site while the GlcNAc residue on this arm occupies a subsite that is almost identical to that of concanavalin A (con A). The core mannose and the GlcNAc beta(1-2)Man moiety on the 1-3 arm on the other hand occupy a series of subsites distinct from those of con A. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Amiot, N.]] | [[Category: Amiot, N.]] | ||
[[Category: Beeckmans, S.]] | [[Category: Beeckmans, S.]] | ||
| - | [[Category: Boons, G | + | [[Category: Boons, G J.]] |
[[Category: Buts, L.]] | [[Category: Buts, L.]] | ||
[[Category: Garcia-Pino, A.]] | [[Category: Garcia-Pino, A.]] | ||
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[[Category: lectin]] | [[Category: lectin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:30:14 2008'' |
Revision as of 14:30, 21 February 2008
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Pterocarpus angolensis Lectin (PAL) In Complex With The Pentasaccharide M592
Overview
The crystal structure of Pterocarpus angolensis lectin is determined in its ligand-free state, in complex with the fucosylated biantennary complex type decasaccharide NA2F, and in complex with a series of smaller oligosaccharide constituents of NA2F. These results together with thermodynamic binding data indicate that the complete oligosaccharide binding site of the lectin consists of five subsites allowing the specific recognition of the pentasaccharide GlcNAc beta(1-2)Man alpha(1-3)[GlcNAc beta(1-2)Man alpha(1-6)]Man. The mannose on the 1-6 arm occupies the monosaccharide binding site while the GlcNAc residue on this arm occupies a subsite that is almost identical to that of concanavalin A (con A). The core mannose and the GlcNAc beta(1-2)Man moiety on the 1-3 arm on the other hand occupy a series of subsites distinct from those of con A.
About this Structure
2AR6 is a Single protein structure of sequence from Pterocarpus angolensis with and as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin., Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versees W, Wyns L, Loris R, FEBS J. 2006 Jun;273(11):2407-20. PMID:16704415
Page seeded by OCA on Thu Feb 21 16:30:14 2008
Categories: Pterocarpus angolensis | Single protein | Amiot, N. | Beeckmans, S. | Boons, G J. | Buts, L. | Garcia-Pino, A. | Imberty, A. | Loris, R. | Versees, W. | Wyns, L. | CA | MN | Carbohydrate recognition | Lectin
