2yb8
From Proteopedia
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{{STRUCTURE_2yb8| PDB=2yb8 | SCENE= }} | {{STRUCTURE_2yb8| PDB=2yb8 | SCENE= }} | ||
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===CRYSTAL STRUCTURE OF NURF55 IN COMPLEX WITH SU(Z)12=== | ===CRYSTAL STRUCTURE OF NURF55 IN COMPLEX WITH SU(Z)12=== | ||
| + | {{ABSTRACT_PUBMED_21549310}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/SUZ12_DROME SUZ12_DROME]] Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. [[http://www.uniprot.org/uniprot/CAF1_DROME CAF1_DROME]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.<ref>PMID:8887645</ref><ref>PMID:9419341</ref><ref>PMID:9784495</ref><ref>PMID:12490953</ref><ref>PMID:15456884</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021549310</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021549310</ref><references group="xtra"/><references/> |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Aiwazian, J.]] | [[Category: Aiwazian, J.]] | ||
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[[Category: Zhao, K.]] | [[Category: Zhao, K.]] | ||
[[Category: Zhou, S.]] | [[Category: Zhou, S.]] | ||
| + | [[Category: Chromatin remodelling]] | ||
| + | [[Category: H3k27]] | ||
| + | [[Category: H3k4]] | ||
| + | [[Category: H4]] | ||
| + | [[Category: Histone methlyation]] | ||
| + | [[Category: P55]] | ||
| + | [[Category: Prc2]] | ||
| + | [[Category: Rbap46]] | ||
| + | [[Category: Rbap48]] | ||
| + | [[Category: Rbbp4]] | ||
| + | [[Category: Rbbp7]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Wd40 domain]] | ||
Revision as of 09:36, 27 March 2013
Contents |
CRYSTAL STRUCTURE OF NURF55 IN COMPLEX WITH SU(Z)12
Template:ABSTRACT PUBMED 21549310
Function
[SUZ12_DROME] Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required. [CAF1_DROME] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development. Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2.[1][2][3][4][5]
About this Structure
2yb8 is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
- Schmitges FW, Prusty AB, Faty M, Stutzer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Muller J, Thoma NH. Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks. Mol Cell. 2011 May 6;42(3):330-41. PMID:21549310 doi:10.1016/j.molcel.2011.03.025
- ↑ Tyler JK, Bulger M, Kamakaka RT, Kobayashi R, Kadonaga JT. The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Mol Cell Biol. 1996 Nov;16(11):6149-59. PMID:8887645
- ↑ Martinez-Balbas MA, Tsukiyama T, Gdula D, Wu C. Drosophila NURF-55, a WD repeat protein involved in histone metabolism. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):132-7. PMID:9419341
- ↑ Gdula DA, Sandaltzopoulos R, Tsukiyama T, Ossipow V, Wu C. Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. Genes Dev. 1998 Oct 15;12(20):3206-16. PMID:9784495
- ↑ Beall EL, Manak JR, Zhou S, Bell M, Lipsick JS, Botchan MR. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature. 2002 Dec 19-26;420(6917):833-7. PMID:12490953 doi:10.1038/nature01228
- ↑ Taylor-Harding B, Binne UK, Korenjak M, Brehm A, Dyson NJ. p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes. Mol Cell Biol. 2004 Oct;24(20):9124-36. PMID:15456884 doi:10.1128/MCB.24.20.9124-9136.2004
Categories: Drosophila melanogaster | Aiwazian, J. | Bauer, A. | Bouwmeester, T. | Bunker, R D. | Chan, H. | Faty, M. | Fischle, W. | Gu, J. | Gut, H. | Hess, D. | Li, L. | Lingaraju, G M. | Ly-Hartig, N. | Muller, J. | Prusty, A B. | Sack, R. | Schmitges, F W. | Stutzer, A. | Thoma, N H. | Wirth, U. | Zhao, K. | Zhou, S. | Chromatin remodelling | H3k27 | H3k4 | H4 | Histone methlyation | P55 | Prc2 | Rbap46 | Rbap48 | Rbbp4 | Rbbp7 | Transcription | Wd40 domain
