3q0h
From Proteopedia
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{{STRUCTURE_3q0h| PDB=3q0h | SCENE= }} | {{STRUCTURE_3q0h| PDB=3q0h | SCENE= }} | ||
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===Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)=== | ===Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)=== | ||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN]] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Ramagopal, U A.]] | [[Category: Ramagopal, U A.]] | ||
[[Category: Samanta, D.]] | [[Category: Samanta, D.]] | ||
| + | [[Category: Adhesion]] | ||
| + | [[Category: Immune receptor]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: New york structural genomics research consortium]] | ||
| + | [[Category: Nysgrc]] | ||
| + | [[Category: Psi-biology]] | ||
| + | [[Category: Structural genomic]] | ||
Revision as of 08:28, 8 May 2013
Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)
Function
[TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
About this Structure
3q0h is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
