2cw3
From Proteopedia
(New page: 200px<br /><applet load="2cw3" size="350" color="white" frame="true" align="right" spinBox="true" caption="2cw3, resolution 2.50Å" /> '''X-ray structure of P...) |
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==Overview== | ==Overview== | ||
| - | Perkinsus marinus, a facultative intracellular parasite of the eastern | + | Perkinsus marinus, a facultative intracellular parasite of the eastern oyster Crassostrea virginica, is responsible for mass mortalities of oyster populations. P. marinus trophozoites survive and proliferate within oyster hemocytes, invading most tissues and fluids, thus causing a systemic infection that eventually kills the host. The phagocytosis of P. marinus trophozoites lacks a respiratory burst, suggesting that the parasite has mechanisms that actively abrogate the host's oxidative defense responses. One mechanism and the first line of defense against oxidative damage is the dismutation of superoxide radical to molecular oxygen and hydrogen peroxide by superoxide dismutases (SODs). P. marinus possesses two iron-cofactored SODs, PmSOD1 and PmSOD2. Here, the crystallization and X-ray structures of both PmSOD1 and PmSOD2 are presented. |
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus., Asojo OA, Schott EJ, Vasta GR, Silva AM, Acta | + | Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus., Asojo OA, Schott EJ, Vasta GR, Silva AM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1072-5. Epub 2006 Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17077482 17077482] |
[[Category: Perkinsus marinus]] | [[Category: Perkinsus marinus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Superoxide dismutase]] | [[Category: Superoxide dismutase]] | ||
| - | [[Category: Asojo, O | + | [[Category: Asojo, O A.]] |
| - | [[Category: Schott, E | + | [[Category: Schott, E J.]] |
| - | [[Category: Silva, A | + | [[Category: Silva, A M.]] |
| - | [[Category: Vasta, G | + | [[Category: Vasta, G R.]] |
[[Category: FE]] | [[Category: FE]] | ||
[[Category: sod]] | [[Category: sod]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:52:57 2008'' |
Revision as of 14:52, 21 February 2008
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X-ray structure of PmSOD2, superoxide dismutase from Perkinsus marinus
Overview
Perkinsus marinus, a facultative intracellular parasite of the eastern oyster Crassostrea virginica, is responsible for mass mortalities of oyster populations. P. marinus trophozoites survive and proliferate within oyster hemocytes, invading most tissues and fluids, thus causing a systemic infection that eventually kills the host. The phagocytosis of P. marinus trophozoites lacks a respiratory burst, suggesting that the parasite has mechanisms that actively abrogate the host's oxidative defense responses. One mechanism and the first line of defense against oxidative damage is the dismutation of superoxide radical to molecular oxygen and hydrogen peroxide by superoxide dismutases (SODs). P. marinus possesses two iron-cofactored SODs, PmSOD1 and PmSOD2. Here, the crystallization and X-ray structures of both PmSOD1 and PmSOD2 are presented.
About this Structure
2CW3 is a Single protein structure of sequence from Perkinsus marinus with as ligand. Active as Superoxide dismutase, with EC number 1.15.1.1 Full crystallographic information is available from OCA.
Reference
Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus., Asojo OA, Schott EJ, Vasta GR, Silva AM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1072-5. Epub 2006 Oct 25. PMID:17077482
Page seeded by OCA on Thu Feb 21 16:52:57 2008
