3i65
From Proteopedia
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{{STRUCTURE_3i65| PDB=3i65 | SCENE= }} | {{STRUCTURE_3i65| PDB=3i65 | SCENE= }} | ||
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===Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1=== | ===Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1=== | ||
| + | {{ABSTRACT_PUBMED_19640844}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:019640844</ref><references group="xtra"/> | + | <ref group="xtra">PMID:019640844</ref><references group="xtra"/><references/> |
[[Category: Dihydroorotate oxidase]] | [[Category: Dihydroorotate oxidase]] | ||
[[Category: Plasmodium falciparum 3d7]] | [[Category: Plasmodium falciparum 3d7]] | ||
Revision as of 09:29, 27 March 2013
Contents |
Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1
Template:ABSTRACT PUBMED 19640844
Function
[PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
About this Structure
3i65 is a 1 chain structure with sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.
Reference
- Deng X, Gujjar R, El Mazouni F, Kaminsky W, Malmquist NA, Goldsmith EJ, Rathod PK, Phillips MA. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J Biol Chem. 2009 Sep 25;284(39):26999-7009. Epub 2009 Jul 28. PMID:19640844 doi:10.1074/jbc.M109.028589
Categories: Dihydroorotate oxidase | Plasmodium falciparum 3d7 | Deng, X. | Phillips,M A. | Dihydroorotate dehydrogenase | Dsm1 | Fad | Flavoprotein | Inhibitor | Membrane | Mitochondrion | Mitochondrion inner membrane | Oxidoreductase | Plasmodium falciparum | Pyrimidine biosynthesis | Transit peptide | Triazolopyrimidine
