2qmq

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[[Image:2qmq.png|left|200px]]
 
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{{STRUCTURE_2qmq| PDB=2qmq | SCENE= }}
{{STRUCTURE_2qmq| PDB=2qmq | SCENE= }}
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===Crystal structure of a n-myc downstream regulated 2 protein (ndrg2, syld, ndr2, ai182517, au040374) from mus musculus at 1.70 A resolution===
===Crystal structure of a n-myc downstream regulated 2 protein (ndrg2, syld, ndr2, ai182517, au040374) from mus musculus at 1.70 A resolution===
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{{ABSTRACT_PUBMED_21247902}}
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==Function==
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[[http://www.uniprot.org/uniprot/NDRG2_MOUSE NDRG2_MOUSE]] Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity).
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{{ABSTRACT_PUBMED_21247902}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021247902</ref><references group="xtra"/>
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<ref group="xtra">PMID:021247902</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: JCSG, Joint Center for Structural Genomics.]]
[[Category: JCSG, Joint Center for Structural Genomics.]]

Revision as of 21:02, 17 April 2013

Template:STRUCTURE 2qmq

Contents

Crystal structure of a n-myc downstream regulated 2 protein (ndrg2, syld, ndr2, ai182517, au040374) from mus musculus at 1.70 A resolution

Template:ABSTRACT PUBMED 21247902

Function

[NDRG2_MOUSE] Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity).

About this Structure

2qmq is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Hwang J, Kim Y, Kang HB, Jaroszewski L, Deacon A, Lee H, Choi WC, Kim KJ, Kim CH, Kang BS, Lee JO, Oh TK, Kim JW, Wilson IA, Kim MH. Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor. J Biol Chem. 2011 Jan 18. PMID:21247902 doi:10.1074/jbc.M110.170803

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OCA

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