3qzv

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[[Image:3qzv.jpg|left|200px]]
 
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{{STRUCTURE_3qzv| PDB=3qzv | SCENE= }}
{{STRUCTURE_3qzv| PDB=3qzv | SCENE= }}
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===Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide===
===Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide===
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{{ABSTRACT_PUBMED_21596426}}
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==Function==
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[[http://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
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{{ABSTRACT_PUBMED_21596426}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021596426</ref><references group="xtra"/>
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<ref group="xtra">PMID:021596426</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Li, H.]]
[[Category: Li, H.]]

Revision as of 07:50, 16 May 2013

Template:STRUCTURE 3qzv

Contents

Crystal Structure of BPTF PHD-linker-bromo in complex with histone H4K12ac peptide

Template:ABSTRACT PUBMED 21596426

Function

[BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.

About this Structure

3qzv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Ruthenburg AJ, Li H, Milne TA, Dewell S, McGinty RK, Yuen M, Ueberheide B, Dou Y, Muir TW, Patel DJ, Allis CD. Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions. Cell. 2011 May 27;145(5):692-706. Epub 2011 May 19. PMID:21596426 doi:10.1016/j.cell.2011.03.053

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