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2yc1

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[[Image:2yc1.png|left|200px]]
 
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{{STRUCTURE_2yc1| PDB=2yc1 | SCENE= }}
{{STRUCTURE_2yc1| PDB=2yc1 | SCENE= }}
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===CRYSTAL STRUCTURE OF THE HUMAN DERIVED SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) 9004G IN COMPLEX WITH CN2 TOXIN FROM THE SCORPION CENTRUROIDES NOXIUS HOFFMANN===
===CRYSTAL STRUCTURE OF THE HUMAN DERIVED SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) 9004G IN COMPLEX WITH CN2 TOXIN FROM THE SCORPION CENTRUROIDES NOXIUS HOFFMANN===
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{{ABSTRACT_PUBMED_21489992}}
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==Function==
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[[http://www.uniprot.org/uniprot/SCX2_CENNO SCX2_CENNO]] Mammal beta-toxins bind voltage-independently at site-4 of sodium channels and shift the activation voltage to more negative potentials. This toxin is active against mammals.
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{{ABSTRACT_PUBMED_21489992}}
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==About this Structure==
==About this Structure==
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[[2yc1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_noxius_hoffmann Centruroides noxius hoffmann] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YC1 OCA].
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[[2yc1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_noxius Centruroides noxius] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YC1 OCA].
==Reference==
==Reference==
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<ref group="xtra">PMID:021489992</ref><references group="xtra"/>
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<ref group="xtra">PMID:021489992</ref><references group="xtra"/><references/>
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[[Category: Centruroides noxius hoffmann]]
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[[Category: Centruroides noxius]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Becerril, B.]]
[[Category: Becerril, B.]]

Revision as of 21:17, 17 April 2013

Template:STRUCTURE 2yc1

Contents

CRYSTAL STRUCTURE OF THE HUMAN DERIVED SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) 9004G IN COMPLEX WITH CN2 TOXIN FROM THE SCORPION CENTRUROIDES NOXIUS HOFFMANN

Template:ABSTRACT PUBMED 21489992

Function

[SCX2_CENNO] Mammal beta-toxins bind voltage-independently at site-4 of sodium channels and shift the activation voltage to more negative potentials. This toxin is active against mammals.

About this Structure

2yc1 is a 6 chain structure with sequence from Centruroides noxius and Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Canul-Tec JC, Riano-Umbarila L, Rudino-Pinera E, Becerril B, Possani LD, Torres-Larios A. Structural Basis of Neutralization of the Major Toxic Component from the Scorpion Centruroides noxius Hoffmann by a Human-derived Single-chain Antibody Fragment. J Biol Chem. 2011 Jun 10;286(23):20892-900. Epub 2011 Apr 13. PMID:21489992 doi:10.1074/jbc.M111.238410

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