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3rvg

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'''Unreleased structure'''
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[[Image:3rvg.jpg|left|200px]]
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The entry 3rvg is ON HOLD until Paper Publication
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{{STRUCTURE_3rvg| PDB=3rvg | SCENE= }}
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Authors: Su, H.P.
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===Crystals structure of Jak2 with a 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitor===
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Description: Crystal structure of a JAK2 inhibitor
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{{ABSTRACT_PUBMED_21942426}}
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==About this Structure==
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[[3rvg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RVG OCA].
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==Reference==
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<ref group="xtra">PMID:021942426</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Altman, M D.]]
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[[Category: Chan, G.]]
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[[Category: Dinsmore, C J.]]
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[[Category: Lim, J.]]
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[[Category: Marshall, C G.]]
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[[Category: Otte, R D.]]
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[[Category: Rosenstein, C.]]
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[[Category: Sharma, S.]]
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[[Category: Spencer, K.]]
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[[Category: Su, H P.]]
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[[Category: Szewczak, A A.]]
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[[Category: Taoka, B.]]
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[[Category: Xu, L.]]
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[[Category: Yin, H.]]
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[[Category: Young, J R.]]
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[[Category: Zugay-Murphy, J.]]
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[[Category: Enzyme inhibitor]]
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[[Category: Janus kinase 2]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Tyrosine kinase]]

Revision as of 07:29, 21 March 2012

Image:3rvg.jpg

Template:STRUCTURE 3rvg

Crystals structure of Jak2 with a 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitor

Template:ABSTRACT PUBMED 21942426

About this Structure

3rvg is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Lim J, Taoka B, Otte RD, Spencer K, Dinsmore CJ, Altman MD, Chan G, Rosenstein C, Sharma S, Su HP, Szewczak AA, Xu L, Yin H, Zugay-Murphy J, Marshall CG, Young JR. Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. J Med Chem. 2011 Oct 27;54(20):7334-49. Epub 2011 Sep 26. PMID:21942426 doi:10.1021/jm200909u

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