3rt4

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[[Image:3rt4.jpg|left|200px]]
 
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{{STRUCTURE_3rt4| PDB=3rt4 | SCENE= }}
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===Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein===
===Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein===
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{{ABSTRACT_PUBMED_21454594}}
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==Function==
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[[http://www.uniprot.org/uniprot/PGRP1_CAMDR PGRP1_CAMDR]] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).
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{{ABSTRACT_PUBMED_21454594}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021454594</ref><references group="xtra"/>
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<ref group="xtra">PMID:021454594</ref><references group="xtra"/><references/>
[[Category: Camelus dromedarius]]
[[Category: Camelus dromedarius]]
[[Category: Dey, S.]]
[[Category: Dey, S.]]

Revision as of 07:58, 16 May 2013

Template:STRUCTURE 3rt4

Contents

Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein

Template:ABSTRACT PUBMED 21454594

Function

[PGRP1_CAMDR] Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. May function in intracellular killing of bacteria (By similarity).

About this Structure

3rt4 is a 4 chain structure with sequence from Camelus dromedarius. This structure supersedes the now removed PDB entry 3mu9. Full crystallographic information is available from OCA.

Reference

  • Sharma P, Dube D, Singh A, Mishra B, Singh N, Sinha M, Dey S, Kaur P, Mitra DK, Sharma S, Singh TP. Structural Basis of Recognition of Pathogen-associated Molecular Patterns and Inhibition of Proinflammatory Cytokines by Camel Peptidoglycan Recognition Protein. J Biol Chem. 2011 May 6;286(18):16208-17. Epub 2011 Mar 21. PMID:21454594 doi:10.1074/jbc.M111.228163

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OCA

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