Mitogen-activated protein kinase kinase
From Proteopedia
| Line 13: | Line 13: | ||
== 3D Structures of Mitogen-activated protein kinase kinase == | == 3D Structures of Mitogen-activated protein kinase kinase == | ||
| - | ''Update | + | ''Update November 2011'' |
===MAP2K1=== | ===MAP2K1=== | ||
| Line 22: | Line 22: | ||
[[3eqg]], [[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br /> | [[3eqg]], [[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br /> | ||
[[3eqh]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor<br /> | [[3eqh]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor<br /> | ||
| + | [[3orn]] - hMAP2K1 kinase domain +MgAMP-PNP +inhibitor<br /> | ||
| + | [[3os3]], [[3pp1]] - hMAP2K1 kinase domain + MgATP +inhibitor<br /> | ||
[[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br /> | [[3eqi]] - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd<br /> | ||
[[3dv3]] - hMAP2K1 residues 62-382+inhibitor<br /> | [[3dv3]] - hMAP2K1 residues 62-382+inhibitor<br /> | ||
| Line 27: | Line 29: | ||
[[1sko]] - hMAP2K1+P14<br /> | [[1sko]] - hMAP2K1+P14<br /> | ||
[[3cpt]] - hMAP2K1+P14 (mutant)<br /> | [[3cpt]] - hMAP2K1+P14 (mutant)<br /> | ||
| - | [[1vet]], [[1veu]] - MAP2K1+P14 - mouse | + | [[2y4i]] – MAP2K1 + kinase suppressor of RAS 2 - rabbit<br /> |
| + | [[1vet]], [[1veu]] - MAP2K1+P14 - mouse<br /> | ||
| + | |||
===MAP2K2=== | ===MAP2K2=== | ||
| Line 41: | Line 45: | ||
[[3aln]] - hMAP2K4 kinase domain +AMPPNP<br /> | [[3aln]] - hMAP2K4 kinase domain +AMPPNP<br /> | ||
| + | [[3alo]] - hMAP2K4 kinase domain + P38 peptide | ||
===MAP2K5=== | ===MAP2K5=== | ||
| Line 47: | Line 52: | ||
===MAP2K6=== | ===MAP2K6=== | ||
| + | |||
| + | [[3an0]] - hMAP2K6<br /> | ||
[[3enm]] – hMAP2K6 (mutant)<br /> | [[3enm]] – hMAP2K6 (mutant)<br /> | ||
[[3fme]] – hMAP2K6 kinase domain (mutant)<br /> | [[3fme]] – hMAP2K6 kinase domain (mutant)<br /> | ||
Revision as of 10:57, 15 November 2011
Mitogen-activated protein kinase kinase (MAP2K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP2K is part of the MAPK cascade which consists also of MAPK and MAP3K which are activated by phosphorylation. MAP2K activates MAPK. The images on the left and right correspond to one representative MAP2K structure, i.e. the human MAP2K1 (3e8n).
Contents |
3D Structures of Mitogen-activated protein kinase kinase
Update November 2011
MAP2K1
3mbl, 3e8n, 3dy7, 3eqb, 2p55 – hMAP2K1 kinase domain +MgADP+ligand - human
3eqc – hMAP2K1 kinase domain+ATP-Gs+Mg2P
3eqd - hMAP2K1 kinase domain (mutant)+ATP-Gs+Mg2P
3eqf - hMAP2K1 kinase domain (mutant)+inhibitor+Mg2P
3eqg, 3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd
3eqh - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor
3orn - hMAP2K1 kinase domain +MgAMP-PNP +inhibitor
3os3, 3pp1 - hMAP2K1 kinase domain + MgATP +inhibitor
3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd
3dv3 - hMAP2K1 residues 62-382+inhibitor
1s9j – hMAP2K1 +MgATP+ligand
1sko - hMAP2K1+P14
3cpt - hMAP2K1+P14 (mutant)
2y4i – MAP2K1 + kinase suppressor of RAS 2 - rabbit
1vet, 1veu - MAP2K1+P14 - mouse
MAP2K2
1s9i – hMAP2K2 +MgATP+ligand
1jky - hMAP2K2 + Anthrax lethal factor
MAP2K3
2o2v – hMAP2K3+ hMAP3K5
MAP2K4
3aln - hMAP2K4 kinase domain +AMPPNP
3alo - hMAP2K4 kinase domain + P38 peptide
MAP2K5
1p38 – hMAP2K5+hMAP2KK2
MAP2K6
3an0 - hMAP2K6
3enm – hMAP2K6 (mutant)
3fme – hMAP2K6 kinase domain (mutant)
MAP2K7
2dyl – hMAP2K7 kinase domain (mutant)
