Beta-lactamase
From Proteopedia
| Line 12: | Line 12: | ||
== 3D Structures of Beta-lactamase == | == 3D Structures of Beta-lactamase == | ||
| + | |||
| + | ===β-lactamase class A=== | ||
| + | |||
| + | [[3dtm]] - EcBlac A residues 24-286 (mutant) - Escherichia coli<br /> | ||
| + | [[3c7u]], [[3c7v]] – EcBlac A (mutant) + Protein Blip<br /> | ||
| + | [[1axb]] - EcBlac A (mutant) + transition state analog<br /> | ||
| + | [[1tem]] - EcBlac A (mutant) + penicillanic acid derivative<br /> | ||
| + | [[1o7e]] – Blac – Stenotrophonas maltophilia | ||
| + | |||
| + | ===β-lactamase class B=== | ||
| + | |||
| + | [[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]] – BcBlac B - Bacillus cereus<br /> | ||
| + | [[3knr]], [[3kns]] - BcBlac C (mutant) | ||
| + | |||
| + | ===β-lactamase class C=== | ||
| + | |||
| + | [[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br /> | ||
| + | [[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid derivative<br /> | ||
| + | [[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid derivative<br /> | ||
| + | [[3ixh]] - EcBlac C (mutant) + cefotaxime<br /> | ||
| + | [[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]] - EcBlac C + inhibitor | ||
| + | |||
| + | ===β-lactamase class D=== | ||
| + | |||
| + | [[2rl3]], [[1k55]], [[1k57]], [[1k4e]], [[1ewz]], [[1fof]] – PaBlac D – Pseudomonas aeruginosa<br /> | ||
| + | [[2hp5]], [[2hp6]], [[2hp9]], [[2hpb]] - PaBlac D (mutant) <br /> | ||
| + | [[1k6r]] - PaBlac D + moxalactam<br /> | ||
| + | [[1k6s]] - PaBlac D + phenylboronic acid<br /> | ||
| + | [[1k54]] - PaBlac D + penicillanic acid derivative<br /> | ||
| + | |||
| + | [[1bsg]] – Blac – Streptomyces albus | ||
| + | |||
| + | |||
| + | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:38, 19 June 2011
Beta-lactamase (Blac) are enzymes which make bacteria resitant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases.
Contents |
3D Structures of Beta-lactamase
β-lactamase class A
3dtm - EcBlac A residues 24-286 (mutant) - Escherichia coli
3c7u, 3c7v – EcBlac A (mutant) + Protein Blip
1axb - EcBlac A (mutant) + transition state analog
1tem - EcBlac A (mutant) + penicillanic acid derivative
1o7e – Blac – Stenotrophonas maltophilia
β-lactamase class B
3fcz, 3i0v, 3i11, 3i13, 3i14, 3i15 – BcBlac B - Bacillus cereus
3knr, 3kns - BcBlac C (mutant)
β-lactamase class C
3fkw, 3iwi, 3iwo, 3iwq, 3ixd – EcBlac C (mutant)
3bm6, 3fkv, 3o86, 3o87, 3o88 – EcBlac C + boronic acid derivative
3ixb, 3ixg - EcBlac C (mutant) + boronic acid derivative
3ixh - EcBlac C (mutant) + cefotaxime
3gqz, 3gr2, 3grj, 3gsg, 3gtc, 3gv9, 3gvb - EcBlac C + inhibitor
β-lactamase class D
2rl3, 1k55, 1k57, 1k4e, 1ewz, 1fof – PaBlac D – Pseudomonas aeruginosa
2hp5, 2hp6, 2hp9, 2hpb - PaBlac D (mutant)
1k6r - PaBlac D + moxalactam
1k6s - PaBlac D + phenylboronic acid
1k54 - PaBlac D + penicillanic acid derivative
1bsg – Blac – Streptomyces albus
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman
