Proteasome
From Proteopedia
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[[Image:3gpt.jpg|left|200px|thumb|Crystal Structure of Proteasome, [[3gpt]]]] | [[Image:3gpt.jpg|left|200px|thumb|Crystal Structure of Proteasome, [[3gpt]]]] | ||
| - | {{STRUCTURE_3gpt| PDB=3gpt | SIZE=300| SCENE= |right|CAPTION=Proteasome, [[3gpt]] }} | + | {{STRUCTURE_3gpt| PDB=3gpt | SIZE=300| SCENE= |right|CAPTION=Proteasome complex with salinosporamide derivative, [[3gpt]] }} |
Revision as of 09:03, 19 June 2011
Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 alpha subunits which form the PRTS gate. The two inner rings contain 6 beta subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which binds polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, i.e. the crystal structure of yeast Proteasome (3gpt).
Contents |
3D Structures of Proteasome
Update June 2011
20S particle
3mfe, 3mi0, 2fhg – Mt20S core – Mycobacterium tuberculosis
3gpt, 3gpw, 1g0u – y20S core - yeast
1ryp - y20S core (mutant)
2zcy – y20S+syringolin
3mka, 3hfa – Mt20S core (mutant)
3c91, 3c92, 1pma – Ta20S core - Themoplasma acidophilum
3h4p – 20S core – Methanocaldococcus janaschii
2h6j, 1q5r – Re20S core (mutant) – Rhodococcus erythropolis
1q5q - Re20S core
1j2q – Af20S core - Archaeoglobus fulgidus
1iru – 20S core - bovine
20S+activator protein
1vsy, 1l5q – y20S core+ Blm10
1z7q, 1fnt – y20S core+PA26
3ipm, 3jrm, 3jse, 3jtl, 1ya7, 1yar, 1yau - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U
20S+inhibitor
3hye, 3gpj, 3dy3, 3dy4, 3e47, 3d29, 3bdm, 2zcy, 2gpl, 2fak, 2f16, 1jd2, 1g65, 3mg0, 3mg4, 3mg6, 3mg7, 3mg8 – y20S core+inhibitor
3h6f, 3h6i, 3hf9, 2fhh, 3krd – Mt20S core+inhibitor
3nzj, 3nzw, 3nzx - y20S + TMC-95A mimic ligand
Partial 20S
2ku1, 2ku2 – Taa-PRTS chains A-G
3fp9 – MtATPase chains A-L
1j2p – Af α subunit
2jay – Mt β subunit
2kqz, 2kr0 – hPRTS ubiquitin receptor domain
Partial 26S
1p9c – hPRTS subunit 4 C-terminal – human
1p9d - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain
1uel - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR
1yx4 - hPRTS subunit 4 – NMR
1yx5, 1yx6, 2kde, 2kdf - hPRTS subunit 4+ubiquitin – NMR
2o95, 2o96 - hPRTS subunit 7
3kw6 - hPRTS subunit 8
2krk - hPRTS subunit 8 – NMR
1qym, 1uoh - hPRTS subunit 10
1tr4 - hPRTS subunit 10 – NMR
2dvw, 2dwz - mPRTS subunit 10 + hPRTS subunit 6B – mouse
3aji - mPRTS subunit 10 + subunit 4
2x5n - PRTS subunit RPN10 VWA domain – fission yeast
2z4d - yPRTS subunit RPN13
2z59 - mPRTS subunit RPN13+ubiquitin
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
