2yg2

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[[Image:2yg2.jpg|left|200px]]
 
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{{STRUCTURE_2yg2| PDB=2yg2 | SCENE= }}
{{STRUCTURE_2yg2| PDB=2yg2 | SCENE= }}
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===STRUCTURE OF APOLIOPROTEIN M IN COMPLEX WITH SPHINGOSINE 1-PHOSPHATE===
===STRUCTURE OF APOLIOPROTEIN M IN COMPLEX WITH SPHINGOSINE 1-PHOSPHATE===
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{{ABSTRACT_PUBMED_21606363}}
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==Function==
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[[http://www.uniprot.org/uniprot/APOM_HUMAN APOM_HUMAN]] Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.<ref>PMID:17525477</ref> <ref>PMID:19733574</ref>
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{{ABSTRACT_PUBMED_21606363}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:021606363</ref><references group="xtra"/>
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<ref group="xtra">PMID:021606363</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ahnstrom, J.]]
[[Category: Ahnstrom, J.]]

Revision as of 11:56, 24 April 2013

Template:STRUCTURE 2yg2

Contents

STRUCTURE OF APOLIOPROTEIN M IN COMPLEX WITH SPHINGOSINE 1-PHOSPHATE

Template:ABSTRACT PUBMED 21606363

Function

[APOM_HUMAN] Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.[1] [2]

About this Structure

2yg2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnstrom J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlback B. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8. Epub 2011 May 23. PMID:21606363 doi:10.1073/pnas.1103187108
  1. ↑ Ahnstrom J, Faber K, Axler O, Dahlback B. Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M. J Lipid Res. 2007 Aug;48(8):1754-62. Epub 2007 May 24. PMID:17525477 doi:10.1194/jlr.M700103-JLR200
  2. ↑ Sevvana M, Ahnstrom J, Egerer-Sieber C, Lange HA, Dahlback B, Muller YA. Serendipitous fatty acid binding reveals the structural determinants for ligand recognition in apolipoprotein M. J Mol Biol. 2009 Nov 6;393(4):920-36. Epub 2009 Sep 4. PMID:19733574 doi:10.1016/j.jmb.2009.08.071

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OCA

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