3sfk

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m (Protected "3sfk" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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[[Image:3sfk.jpg|left|200px]]
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The entry 3sfk is ON HOLD until Paper Publication
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{{STRUCTURE_3sfk| PDB=3sfk | SCENE= }}
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Authors: Deng, X., Phillips, M.
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===Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267===
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Description: Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267
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{{ABSTRACT_PUBMED_21696174}}
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==About this Structure==
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[[3sfk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFK OCA].
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==Reference==
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<ref group="xtra">PMID:021696174</ref><references group="xtra"/>
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[[Category: Dihydroorotate dehydrogenase]]
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[[Category: Plasmodium falciparum 3d7]]
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[[Category: Deng, X.]]
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[[Category: Phillips, M.]]
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[[Category: Alpha beta barrel oxidoreductase]]
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[[Category: Alpha beta fold]]
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[[Category: Flavoprotein]]
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[[Category: Fmn]]
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[[Category: Inhibitor dsm267]]
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[[Category: Mitochondrion inner membrane]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Plasmodium falciparum membrane mitochondrion]]
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[[Category: Pyrimidine biosynthesis]]

Revision as of 18:43, 6 July 2011

Image:3sfk.jpg

Template:STRUCTURE 3sfk

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267

Template:ABSTRACT PUBMED 21696174

About this Structure

3sfk is a 1 chain structure with sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.

Reference

  • Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford D, Barturen I, Ferrer S, Jimenez-Diaz MB, Gamo FJ, Goldsmith EJ, Charman B, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem. 2011 Jun 22. PMID:21696174 doi:10.1021/jm200592f

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OCA

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