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2fom

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(New page: 200px<br /><applet load="2fom" size="350" color="white" frame="true" align="right" spinBox="true" caption="2fom, resolution 1.50&Aring;" /> '''Dengue Virus NS2B/NS...)
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==Overview==
==Overview==
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The replication of flaviviruses requires the correct processing of their, polyprotein by the viral NS3 protease (NS3pro). Essential for the, activation of NS3pro is a 47-residue region of NS2B. Here we report the, crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus, NS2B-NS3pro complex with a substrate-based inhibitor. These structures, identify key residues for NS3pro substrate recognition and clarify the, mechanism of NS3pro activation.
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The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
==About this Structure==
==About this Structure==
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[[Category: Flavivirin]]
[[Category: Flavivirin]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Arcy, A.D.]]
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[[Category: Arcy, A D.]]
[[Category: Erbel, P.]]
[[Category: Erbel, P.]]
[[Category: Kroemer, M.]]
[[Category: Kroemer, M.]]
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[[Category: ns3 protease]]
[[Category: ns3 protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:41:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:23:36 2008''

Revision as of 15:23, 21 February 2008

Image:2fom.gif

2fom, resolution 1.50Å

Drag the structure with the mouse to rotate

Dengue Virus NS2B/NS3 Protease

Overview

The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.

About this Structure

2FOM is a Protein complex structure of sequences from Dengue virus type 3 with and as ligands. Active as Flavivirin, with EC number 3.4.21.91 Full crystallographic information is available from OCA.

Reference

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:16532006

Page seeded by OCA on Thu Feb 21 17:23:36 2008

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