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RNA polymerase

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[[3q22]], [[3q23]], [[3q24]] – RNAP + DNA – Enterobacteria phage N4<br />
[[3q22]], [[3q23]], [[3q24]] – RNAP + DNA – Enterobacteria phage N4<br />
[[3p8b]] – PfRNAP subunit ε’’ + transcription antitermination protein – ''Pyrococcus furiosus''<br />
[[3p8b]] – PfRNAP subunit ε’’ + transcription antitermination protein – ''Pyrococcus furiosus''<br />
-
[[3lpe]] - RNAP subunit ε’’ + transcription antitermination protein – ''Methanocaldococcus jannaschii''<br />
+
[[3qqc]] - PfRNAP subunits β,ε’’ + transcription antitermination protein<br />
 +
[[1ryq]] - PfRNAP subunit ε’’<br />
 +
[[3lpe]] - MjRNAP subunit ε’’ + transcription antitermination protein – ''Methanocaldococcus jannaschii''<br />
 +
[[1go3]] – MjRNAP subunit RPB4, RPB7<br />
[[3aoh]], [[3aoi]] - TtRNAP subunits α,β,β’,ω + DNA +RNA + GFH1 – ''Thermus thermophilus''<br />
[[3aoh]], [[3aoi]] - TtRNAP subunits α,β,β’,ω + DNA +RNA + GFH1 – ''Thermus thermophilus''<br />
 +
[[2o5i]], [[2o5j]] - TtRNAP subunits α,β,β’,ω + DNA +RNA<br />
 +
[[1iw7]], [[1smy]] - TtRNAP subunits α,β,β’,ω<br />
 +
[[1zyr]], [[2a68]], [[2a69]], [[2a6e]], [[2a6h]] - TtRNAP subunits α,β,β’,ω + antibiotic<br />
 +
[[2ppb]] - TtRNAP subunits α,β,β’,ω + antibiotic + DNA + RNA + substrate analog<br />
 +
[[2be5]] - TtRNAP subunits α,β,β’,ω + σ factor + inhibitor<br />
 +
[[2cw0]] - TtRNAP subunits α,β,β’,ω + σ factor<br />
 +
[[3dxj]], [[3eql]] - TtRNAP subunits α,β,β’,ω + σ factor + antibiotic<br />
 +
[[1doq]] - TtRNAP subunit α<br />
[[3mlq]] - TtRNAP subunit β + transcription-repair coupling factor<br />
[[3mlq]] - TtRNAP subunit β + transcription-repair coupling factor<br />
[[3lti]] – EcRNAP subunit β fragment – ''Escherichia coli''<br />
[[3lti]] – EcRNAP subunit β fragment – ''Escherichia coli''<br />
[[3mmp]] - EcRNAP subunit β + EF-TU<br />
[[3mmp]] - EcRNAP subunit β + EF-TU<br />
-
[[3k4g]] - EcRNAP subunit α<br />
+
[[3k4g]], [[1coo]] - EcRNAP subunit α<br />
 +
[[1lb2]] - EcRNAP subunit α + DNA + CAP<br />
 +
[[1xs9]] - EcRNAP subunit α + DNA + MARA<br />
 +
[[1bdf]] - EcRNAP subunit α (mutant)<br />
[[3lu0]] - EcRNAP subunits α,β,β’,ω – Electron diffraction<br />
[[3lu0]] - EcRNAP subunits α,β,β’,ω – Electron diffraction<br />
[[3iyd]] - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + catabolite gene activator + DNA<br />
[[3iyd]] - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + catabolite gene activator + DNA<br />
[[2l0i]] – yRNAP C-terminal + RTT103 – yeast – NMR<br />
[[2l0i]] – yRNAP C-terminal + RTT103 – yeast – NMR<br />
 +
[[1a1d]] – yRNAP subunit RPB8 – NMR<br />
[[2krc]] - BsRNAP subunit δ N-terminal – ''Bacillus subtilis'' – NMR<br />
[[2krc]] - BsRNAP subunit δ N-terminal – ''Bacillus subtilis'' – NMR<br />
-
[[3ihq]] - BsRNAP subunit α +regulatory protein SPX<br />
+
[[3ihq]], [[1z3e]], [[3gfk]] - BsRNAP subunit α +regulatory protein SPX<br />
 +
[[1qyp]] – RNAP II C terminal – ''Thermococcus celer'' – NMR<br />
 +
[[3ef0]], [[3ef1]] - SpRNAP II subunit α C terminal – ''Schizosaccharomyces pombe''<br />
 +
[[3h0g]] – SpRNAP II<br />
===Eukaryotic DNA-dependent RNAP===
===Eukaryotic DNA-dependent RNAP===
-
[[3o2q]], [[3o2s]] – RNAP II subunit α C-terminal + symplekin – human<br />
+
[[3o2q]], [[3o2s]] – hRNAP II subunit α C-terminal + symplekin – human<br />
 +
[[1qkl]] - hRNAP II subunit RPB6<br />
 +
[[2c35]] - hRNAP II subunits RPB4 RPB7 (mutant) – NMR<br />
 +
[[2f3i]] - hRNAP II subunits RPB8 RPB17 RPABC3 – NMR<br />
 +
[[2ghq]], [[2ght]] - hRNAP II subunits RPB1 + hRNAP II C terminal<br />
 +
[[2q5e]], [[3l0b]], [[3l0c]] - hRNAP II C terminal<br />
 +
[[3pgl]] - hRNAP II C terminal + inhibitor<br />
 +
[[2xub]], [[2xv4]] - hRNAP III subunits RPC3<br />
 +
[[2dk8]] – RNAP III RPC34 domain - mouse – NMR<br />
 +
[[2dk5]] – hRNAP III winged helix domain (mutant) – NMR<br />
 +
[[2yu3]] - hRNAP III winged helix domain<br />
[[3nff]], [[3nfg]], [[3nfh]], [[3nfi]] – RNAP I fragments (mutant) – ''Candida glabrata''<br />
[[3nff]], [[3nfg]], [[3nfh]], [[3nfi]] – RNAP I fragments (mutant) – ''Candida glabrata''<br />
-
[[3m3y]], [[3m4o]] – yRNAP I,II,III + RNA + DNA<br />
+
[[2rf4]] - yRNAP I subunit RPA4<br />
-
[[3k7a]], [[3k1f]] - yRNAP I,II,III + TFIIB
+
[[1i6h]] - yRNAP II + DNA<br />
 +
[[1nik]], [[1nt9]], [[1wcm]], [[2b8k]], [[3fki]], [[3qt1]], [[1i3q]], [[1i50]], [[1dzf]] – yRNAP II<br />
 +
[[1y14]] - yRNAP II subunits RPB4 RPB7<br />
 +
[[1pqv]], [[1y1v]] - yRNAP II + TFIIS<br />
 +
[[1y1y]] - yRNAP II + TFIIS + DNA +RNA<br />
 +
[[2vum]] - yRNAP II + inhibitor + DNA + RNA<br />
 +
[[3cqz]], [[1k83]] - yRNAP II + inhibitor<br />
 +
[[1r5u]], [[3k7a]], [[3k1f]] - yRNAP II + TFIIB<br />
 +
[[1r9s]], [[2ja5]], [[2ja6]], [[2ja7]], [[2ja8]], [[2nvq]], [[2nvt]], [[2nvx]], [[2nvy]], [[2nvz]], [[3gtg]], [[3gtj]], [[3gtk]], [[3gtl]], [[3gtm]], [[3gto]], [[3gtp]], [[3gtq]], [[3hou]], [[3hov]], [[3how]], [[3hox]], [[3hoy]], [[3hoz]], [[3po2]], [[3po3]], [[3m3y]], [[3m4o]] - yRNAP II + RNA + DNA<br />
 +
[[1y1w]], [[1y77]], [[2r7z]], [[2r92]], [[2r93]], [[3h3v]] - yRNAP II + RNA<br />
 +
[[1twa]], [[1twc]], [[1twf]], [[1twg]], [[1twh]] - yRNAP II + nucleotide<br />
 +
[[2b63]] - yRNAP II + nucleotide + RNA<br />
 +
[[2e2i]], [[2e2j]] - yRNAP II + nucleotide + DNA<br />
 +
[[2yu9]], [[3i4m]], [[3i4n]] - yRNAP II + nucleotide + DNA + RNA<br />
 +
[[2ckz]] - yRNAP III<br />
 +
[[1ef4]] – MtRNAP subunit RPB10 – ''Methanothermobacter thermautotrophicus''<br />
 +
[[1eik]] - MtRNAP subunit RPB5 – NMR<br />
 +
 
 +
===Prokaryotic DNA-dependent RNAP===
 +
 
 +
[[1hqm]] – TaRNAP subunits α,β,β’,ω − ''Thermus aquaticus''<br />
 +
[[2gho]] - TaRNAP subunits α,β,β’<br />
 +
[[1i6v]], [[1ynj]], [[1ynn]] - TaRNAP subunits α,β,β’,ω + antibiotic<br />
 +
[[1l9u]] - TaRNAP subunits α,β,β’,ω + σ factor<br />
 +
[[1l9z]] - TaRNAP subunits α,β,β’,ω + σ factor + DNA<br />
 +
[[2auj]], [[2auk]] - TaRNAP subunit β’ <br />
 +
[[1xpp]] – RNAP subunit L – ''Thermoplasma acidophilum''<br />
 +
[[2jzb]] – RNAP subunit α + NUSA transcription elongation factor – ''Yersinia pseudotuberculosis''<br />
 +
[[2waq]], [[2wb1]] – RNAP – ''Sulfolobus shibata''<br />
 +
[[3e7h]] – RNAP subunit β – ''Vibrio cholerae''<br />
 +
 
===RNA-dependent RNAP===
===RNA-dependent RNAP===
-
[[3phu]] – HfRNAP L RNA-directed – Hemorrhagic fever virus<br />
+
[[3phu]], [[1khv]], [[1khw]] – HfRNAP L RNA-directed – Hemorrhagic fever virus<br />
-
[[3phw]], [[2pt2]] – HfRNAP + ubiquitin<br />
+
[[3phw]], [[2pt2]], [[3pt2]] – HfRNAP + ubiquitin<br />
[[3phx]] – HfRNAP + ISG15<br />
[[3phx]] – HfRNAP + ISG15<br />
[[3pse]] - HfRNAP + ISG15 (mutant)<br />
[[3pse]] - HfRNAP + ISG15 (mutant)<br />
-
[[2xwh]], [[2xxd]], [[2xhu]], [[2xhw]], [[3i5k]] – HvRNAP NS5B domain – Hepatitis virus<br />
+
[[2xwh]], [[2xxd]], [[2xhu]], [[2xhw]], [[3i5k]], [[1c2p]], [[1csj]], [[1quv]], [[1yuy]], [[1yv2]], [[1yvx]], [[1yvz]], [[3gsz]] – HvRNAP NS5B domain – Hepatitis virus<br />
[[2xym]], [[2xhv]], [[2xi2]] - HvRNAP NS5B domain (mutant)<br />
[[2xym]], [[2xhv]], [[2xi2]] - HvRNAP NS5B domain (mutant)<br />
-
[[2xwy]], [[3mf5]], [[3hkw]], [[3hky]], [[3lkh]], [[3gnv]], [[3gnw]], [[3h98]], [[3g86]], [[3h59]] - HvRNAP NS5B domain + inhibitor<br />
+
[[2xwy]], [[3mf5]], [[3hkw]], [[3hky]], [[3lkh]], [[3gnv]], [[3gnw]], [[3h98]], [[3g86]], [[3h59]], [[1nhu]], [[1nhv]], [[2brk]], [[2brl]], [[2gc8]], [[2giq]], [[2gir]], [[2hai]], [[2hwh]], [[2hwi]], [[2i1r]], [[2ijn]], [[2jc0]], [[2jc1]], [[2qe2]], [[2qe5]], [[2wcx]], [[2who]], [[3ciz]], [[3cj0]], [[3cj2]], [[3cj3]], [[3cj4]], [[3cj5]], [[3cso]], [[3cvk]], [[3fqk]], [[3fql]], [[3gol]], [[3h5s]], [[3h5u]], [[3q0z]], [[3qgd]], [[3qge]], [[3qgf]], [[3qgg]], [[3qgh]], [[3qgi]] - HvRNAP NS5B domain + inhibitor<br />
[[3gyn]] - HvRNAP NS5B domain (mutant) + inhibitor<br />
[[3gyn]] - HvRNAP NS5B domain (mutant) + inhibitor<br />
[[2wrm]] – HvRNAP NS5B domain<br />
[[2wrm]] – HvRNAP NS5B domain<br />

Revision as of 10:43, 23 June 2011

Image:3m3y.png
Crystal Structure of RNA polymerase 3m3y

Template:STRUCTURE 3m3y

Contents

RNA polymerase (RNAP, DNA primase, dnaG) catalyzes the addition of nucleotides to RNA during transcription. DNA primase (DNAP) is RNAP which catalyzes the synthesis of the RNA primer which complements an ssDNA template and initiates DNA synthesis. dnaG is a bacterial primase.

3D Structures of RNA polymerase

Update June 2011

DNA-dependent RNAP

2y0s – RNAP – Sulfolobus shibata
3q22, 3q23, 3q24 – RNAP + DNA – Enterobacteria phage N4
3p8b – PfRNAP subunit ε’’ + transcription antitermination protein – Pyrococcus furiosus
3qqc - PfRNAP subunits β,ε’’ + transcription antitermination protein
1ryq - PfRNAP subunit ε’’
3lpe - MjRNAP subunit ε’’ + transcription antitermination protein – Methanocaldococcus jannaschii
1go3 – MjRNAP subunit RPB4, RPB7
3aoh, 3aoi - TtRNAP subunits α,β,β’,ω + DNA +RNA + GFH1 – Thermus thermophilus
2o5i, 2o5j - TtRNAP subunits α,β,β’,ω + DNA +RNA
1iw7, 1smy - TtRNAP subunits α,β,β’,ω
1zyr, 2a68, 2a69, 2a6e, 2a6h - TtRNAP subunits α,β,β’,ω + antibiotic
2ppb - TtRNAP subunits α,β,β’,ω + antibiotic + DNA + RNA + substrate analog
2be5 - TtRNAP subunits α,β,β’,ω + σ factor + inhibitor
2cw0 - TtRNAP subunits α,β,β’,ω + σ factor
3dxj, 3eql - TtRNAP subunits α,β,β’,ω + σ factor + antibiotic
1doq - TtRNAP subunit α
3mlq - TtRNAP subunit β + transcription-repair coupling factor
3lti – EcRNAP subunit β fragment – Escherichia coli
3mmp - EcRNAP subunit β + EF-TU
3k4g, 1coo - EcRNAP subunit α
1lb2 - EcRNAP subunit α + DNA + CAP
1xs9 - EcRNAP subunit α + DNA + MARA
1bdf - EcRNAP subunit α (mutant)
3lu0 - EcRNAP subunits α,β,β’,ω – Electron diffraction
3iyd - EcRNAP subunits α,β,β’,ω + RNAP sigma factor + catabolite gene activator + DNA
2l0i – yRNAP C-terminal + RTT103 – yeast – NMR
1a1d – yRNAP subunit RPB8 – NMR
2krc - BsRNAP subunit δ N-terminal – Bacillus subtilis – NMR
3ihq, 1z3e, 3gfk - BsRNAP subunit α +regulatory protein SPX
1qyp – RNAP II C terminal – Thermococcus celer – NMR
3ef0, 3ef1 - SpRNAP II subunit α C terminal – Schizosaccharomyces pombe
3h0g – SpRNAP II

Eukaryotic DNA-dependent RNAP

3o2q, 3o2s – hRNAP II subunit α C-terminal + symplekin – human
1qkl - hRNAP II subunit RPB6
2c35 - hRNAP II subunits RPB4 RPB7 (mutant) – NMR
2f3i - hRNAP II subunits RPB8 RPB17 RPABC3 – NMR
2ghq, 2ght - hRNAP II subunits RPB1 + hRNAP II C terminal
2q5e, 3l0b, 3l0c - hRNAP II C terminal
3pgl - hRNAP II C terminal + inhibitor
2xub, 2xv4 - hRNAP III subunits RPC3
2dk8 – RNAP III RPC34 domain - mouse – NMR
2dk5 – hRNAP III winged helix domain (mutant) – NMR
2yu3 - hRNAP III winged helix domain
3nff, 3nfg, 3nfh, 3nfi – RNAP I fragments (mutant) – Candida glabrata
2rf4 - yRNAP I subunit RPA4
1i6h - yRNAP II + DNA
1nik, 1nt9, 1wcm, 2b8k, 3fki, 3qt1, 1i3q, 1i50, 1dzf – yRNAP II
1y14 - yRNAP II subunits RPB4 RPB7
1pqv, 1y1v - yRNAP II + TFIIS
1y1y - yRNAP II + TFIIS + DNA +RNA
2vum - yRNAP II + inhibitor + DNA + RNA
3cqz, 1k83 - yRNAP II + inhibitor
1r5u, 3k7a, 3k1f - yRNAP II + TFIIB
1r9s, 2ja5, 2ja6, 2ja7, 2ja8, 2nvq, 2nvt, 2nvx, 2nvy, 2nvz, 3gtg, 3gtj, 3gtk, 3gtl, 3gtm, 3gto, 3gtp, 3gtq, 3hou, 3hov, 3how, 3hox, 3hoy, 3hoz, 3po2, 3po3, 3m3y, 3m4o - yRNAP II + RNA + DNA
1y1w, 1y77, 2r7z, 2r92, 2r93, 3h3v - yRNAP II + RNA
1twa, 1twc, 1twf, 1twg, 1twh - yRNAP II + nucleotide
2b63 - yRNAP II + nucleotide + RNA
2e2i, 2e2j - yRNAP II + nucleotide + DNA
2yu9, 3i4m, 3i4n - yRNAP II + nucleotide + DNA + RNA
2ckz - yRNAP III
1ef4 – MtRNAP subunit RPB10 – Methanothermobacter thermautotrophicus
1eik - MtRNAP subunit RPB5 – NMR

Prokaryotic DNA-dependent RNAP

1hqm – TaRNAP subunits α,β,β’,ω − Thermus aquaticus
2gho - TaRNAP subunits α,β,β’
1i6v, 1ynj, 1ynn - TaRNAP subunits α,β,β’,ω + antibiotic
1l9u - TaRNAP subunits α,β,β’,ω + σ factor
1l9z - TaRNAP subunits α,β,β’,ω + σ factor + DNA
2auj, 2auk - TaRNAP subunit β’
1xpp – RNAP subunit L – Thermoplasma acidophilum
2jzb – RNAP subunit α + NUSA transcription elongation factor – Yersinia pseudotuberculosis
2waq, 2wb1 – RNAP – Sulfolobus shibata
3e7h – RNAP subunit β – Vibrio cholerae


RNA-dependent RNAP

3phu, 1khv, 1khw – HfRNAP L RNA-directed – Hemorrhagic fever virus
3phw, 2pt2, 3pt2 – HfRNAP + ubiquitin
3phx – HfRNAP + ISG15
3pse - HfRNAP + ISG15 (mutant)
2xwh, 2xxd, 2xhu, 2xhw, 3i5k, 1c2p, 1csj, 1quv, 1yuy, 1yv2, 1yvx, 1yvz, 3gsz – HvRNAP NS5B domain – Hepatitis virus
2xym, 2xhv, 2xi2 - HvRNAP NS5B domain (mutant)
2xwy, 3mf5, 3hkw, 3hky, 3lkh, 3gnv, 3gnw, 3h98, 3g86, 3h59, 1nhu, 1nhv, 2brk, 2brl, 2gc8, 2giq, 2gir, 2hai, 2hwh, 2hwi, 2i1r, 2ijn, 2jc0, 2jc1, 2qe2, 2qe5, 2wcx, 2who, 3ciz, 3cj0, 3cj2, 3cj3, 3cj4, 3cj5, 3cso, 3cvk, 3fqk, 3fql, 3gol, 3h5s, 3h5u, 3q0z, 3qgd, 3qge, 3qgf, 3qgg, 3qgh, 3qgi - HvRNAP NS5B domain + inhibitor
3gyn - HvRNAP NS5B domain (mutant) + inhibitor
2wrm – HvRNAP NS5B domain
2xi3 - HvRNAP NS5B domain (mutant) + nucleotide
3ol6 – PoRNAP (mutant) + RNA – Poliovirus
3ol7, 3ol8, 3ol9, 3ola, 3olb - PoRNAP (mutant) + RNA + nucleotide
2xi5, 2xi7 – RNAP L N-terminal – Bunyavirus
3jsb – RNAP (mutant) – Lymphocytic choriomengitis virus
2wk4 – RNAP (mutant) – Sapporo virus
3klv, 3kmq, 3kms, 3kna – FmRNAP (mutant) + RNA – Foot-and-mouth virus
3koa - FmRNAP (mutant) + RNA + nucleotide
3hw3, 3hw6 - IvRNAP subunit P2 (mutant) – Influenza virus
3hw5 - IvRNAP subunit P2 (mutant) + AMP

DNA primase

3l9q – hDNAP large subunit
3lgb - yDNAP large subunit
3m1m – DNAP RNA polymerase domain – Sulfolobus islandicus
1zt2 - DNAP small + large subunit – Sulfolobus solfataricus
2au3 – DNAP zinc-binding and RNA polymerase domains – Aquifex aeolicus
1v33 - PhDNAP small subunit – Pyrocuccus horikoshii
1v34 - PhDNAP small subunit + nucleotide
1g71 - PfDNAP small subunit
1q57 – T7DNAP/helicase (mutant) – Enterobacteria phage T7
1nui – T7DNAP/helicase primase fragment (mutant)
1cr0 - T7DNAP/helicase helicase domain
1cr1, 1cr2, 1cr4 - T7DNAP/helicase helicase domain + nucleotide

Bacterial primase

2r6c – dnaG helicase binding domain + helicase – Bacillus stearothermophilus
2r6a - GsdnaG helicase binding domain + helicase – Geobacillus stearothermophilus
1d0q - GsDNAP zinc-binding domain
1z8s - GsdnaG dnaB binding domain - NMR
2haj - EcdnaG catalytic domain - NMR
3b39 – EcdnaG catalytic domain + DNA
1t3w – EcdnaG C-terminal
1eqn, 1dd9, 1dde – EcdnaG catalytic core

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Karsten Theis

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