Group:MUZIC:ZASP

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	'''Function'''		'''Function'''
-	Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the oracle of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin....	+	Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the '''''oracle''''' of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin....

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Revision as of 10:40, 24 June 2011

Z-disk alternatively spliced PDZ-motif (ZASP) protein

is a component protein of the striated muscle Z-disk and a member of the enigma family of proteins. Like most enigma family members, it possess an N-terminal PDZ domain and three C-terminal LIM domains. The structure of the N-terminal PDZ domain has been solved (PDB ID: 1RGW)

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

The PDZ domain has recently been characterized to bind a very C-terminal class III motif in myotilin [1] and myozenin, two other Z-disk members prominent during myofibrillogenesis and sarcomerogenesis [[2]].

doi: 10.1083/jcb.146.2.465 http://jcb.rupress.org/content/146/2/465.full

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Function

Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the oracle of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin....