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Group:MUZIC:Nebulin
From Proteopedia
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The Nebulin protein is involved in the structural integrity of the sarcomeres and is linked to many signalling pathways crucial for the maintenance of the sarcomere. | The Nebulin protein is involved in the structural integrity of the sarcomeres and is linked to many signalling pathways crucial for the maintenance of the sarcomere. | ||
| - | The main fucntions of Nebulin are: | + | The main fucntions of Nebulin are <ref> PMID 20940435 </ref>: |
1. To define and regulate the lenght of the thin filament of actin (molecular ruler); | 1. To define and regulate the lenght of the thin filament of actin (molecular ruler); | ||
2. To maintain the alignment of adjacent myofibrills (linker of adjacent Z-disks); | 2. To maintain the alignment of adjacent myofibrills (linker of adjacent Z-disks); | ||
3. To regulate muscle contraction (regulator of cross-bridge cycles). | 3. To regulate muscle contraction (regulator of cross-bridge cycles). | ||
</StructureSection> | </StructureSection> | ||
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== Domains and interactions== | == Domains and interactions== | ||
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==References== | ==References== | ||
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Revision as of 15:50, 1 July 2011
Contents |
Introduction
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Domains and interactions
Glutamic rich region
Nebulin modules
Serine rich region
SH3 domain
The Nebulin SH3 domain adopts a ß-Barrel .
References
- ↑ Ottenheijm CA, Granzier H. Lifting the nebula: novel insights into skeletal muscle contractility. Physiology (Bethesda). 2010 Oct;25(5):304-10. PMID:20940435 doi:10.1152/physiol.00016.2010
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Marie-Cecile Pelissier, Michal Harel, Jaime Prilusky, Nikos Pinotsis
