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Lactoferrin
From Proteopedia
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== 3D Structures of lactoferrin == | == 3D Structures of lactoferrin == | ||
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| + | ''Updated December 2011'' | ||
===Apo lactoferrin=== | ===Apo lactoferrin=== | ||
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[[1blf]] – bLTF + 2Fe – bovine<BR /> | [[1blf]] – bLTF + 2Fe – bovine<BR /> | ||
[[1sdx]] - bLTF C lobe + 3Zn<BR /> | [[1sdx]] - bLTF C lobe + 3Zn<BR /> | ||
| - | [[1nkx]] - bLTF C lobe + 2Zn + | + | [[1nkx]] - bLTF C lobe + 2Zn + Fe<br /> |
| - | [[1b1x]] – hoLTF + 2Fe<br /> | + | [[1b1x]], [[1f9b]] – hoLTF + 2Fe<br /> |
[[1qjm]] – hoLTF + 2Sm<BR /> | [[1qjm]] – hoLTF + 2Sm<BR /> | ||
[[1ce2]], [[1biy]] – buLTF + 2Fe - buffalo<BR /> | [[1ce2]], [[1biy]] – buLTF + 2Fe - buffalo<BR /> | ||
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===Lactoferrin binary complex=== | ===Lactoferrin binary complex=== | ||
| - | [[3sdf]] – bLTF C lobe + lipoteichoic acid + 2Zn + | + | [[3sdf]] – bLTF C lobe + lipoteichoic acid + 2Zn + Fe<br /> |
| - | [[3rgy]] - bLTF C lobe + lipopolysaccharide + Zn + | + | [[3rgy]] - bLTF C lobe + lipopolysaccharide + Zn + Fe<br /> |
| - | [[3kj7]], [[3k0v]], [[2q8j]], [[2o51]], [[2nwj]], [[2dxy]], [[2dwj]], [[2dsf]], [[2ds9]], [[2hca]], [[2dqv]], [[2dp8]], [[2g93]], [[2ays]] - bLTF C lobe + polysaccharide + 2Zn + | + | [[3kj7]], [[3k0v]], [[2q8j]], [[2o51]], [[2nwj]], [[2dxy]], [[2dwj]], [[2dsf]], [[2ds9]], [[2hca]], [[2dqv]], [[2dp8]], [[2g93]], [[2ays]], [[2alu]], [[2dwi]], [[2dyx]], [[2o1l]], [[2p1s]] - bLTF C lobe + polysaccharide + 2Zn + Fe<br /> |
[[2o1l]] - bLTF C lobe + polysaccharide + Zn + Fe<BR /> | [[2o1l]] - bLTF C lobe + polysaccharide + Zn + Fe<BR /> | ||
[[2fa7]], [[2b65]] - bLTF C lobe + polysaccharide + 3Zn + Fe<BR /> | [[2fa7]], [[2b65]] - bLTF C lobe + polysaccharide + 3Zn + Fe<BR /> | ||
| - | [[3iaz]], [[3ib0]], [[3ib1]] - bLTF C lobe (mutant) + NSAID + 2Zn + | + | [[2dvc]], [[2dwa]], [[2dwh]], [[2e0s]], [[2e1s]], [[2h4i]], [[2px1]] - bLTF C lobe + saccharide + 2Zn + Fe<br /> |
| - | [[3e9x]], [[2qje]], [[2zmb]], [[3crb]], [[2nuv]] - bLTF C lobe + NSAID + 2Zn + | + | [[2dxr]] - bLTF C lobe + sorbitol+ 2Zn + Fe<br /> |
| - | [[3o97]], [[3mjn]], [[3cfl]], [[2ocu]] – bLTF C lobe + inhibitor + 2Zn + | + | [[3iaz]], [[3ib0]], [[3ib1]] - bLTF C lobe (mutant) + NSAID + 2Zn + Fe<br /> |
| - | [[3ib2]] - bLTF C lobe (mutant) + inhibitor + 2Zn + | + | [[3e9x]], [[2qje]], [[2zmb]], [[3crb]], [[2nuv]] - bLTF C lobe + NSAID + 2Zn + Fe<br /> |
| - | [[2doj]] - bLTF C lobe + adenosine + 2Zn + | + | [[3o97]], [[3mjn]], [[3cfl]], [[2ocu]], [[3tod]], [[3tus]] – bLTF C lobe + inhibitor + 2Zn + Fe<br /> |
| - | [[3ci8]] - bLTF C lobe + niacin + 2Zn + | + | [[3ib2]] - bLTF C lobe (mutant) + inhibitor + 2Zn + Fe<br /> |
| - | [[2r9j]] - bLTF C lobe + nicotinamide + 2Zn + | + | [[2doj]] - bLTF C lobe + adenosine + 2Zn + Fe<br /> |
| - | [[2r71]] - bLTF C lobe + inositol + 2Zn + | + | [[3ci8]] - bLTF C lobe + niacin + 2Zn + Fe<br /> |
| + | [[2r9j]] - bLTF C lobe + nicotinamide + 2Zn + Fe<br /> | ||
| + | [[2r71]] - bLTF C lobe + inositol + 2Zn + Fe<br /> | ||
| + | [[3ttr]] - bLTF C lobe + anasthetic + 2Zn + Fe<br /> | ||
| + | [[3u72]] - bLTF C lobe + polypeptide + 2Zn + Fe<br /> | ||
[[3ptl]] – bLTF peptide + proteinase K<BR /> | [[3ptl]] – bLTF peptide + proteinase K<BR /> | ||
[[1bjr]] - buLTF peptide + proteinase K<BR /> | [[1bjr]] - buLTF peptide + proteinase K<BR /> | ||
Revision as of 10:37, 4 December 2011
Lactoferrin (LTF) is found in secretory fluids. It is a component of the immune system and has antimicrobial activity. LTF interacts with DNA, RNA, polysaccharides and heparin. LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. For detailed discussion of human lactoferrin see Human lactoferrin.
Contents |
3D Structures of lactoferrin
Updated December 2011
Apo lactoferrin
1i6b, 1b7u – hoLTF – horse
1dtz – cLTF - camel
1cb6, 1lfg, 1lfh – hLTF - human
1u62, 1xv4, 1xv7 - hLTF peptide – NMR
Lactoferrin
1blf – bLTF + 2Fe – bovine
1sdx - bLTF C lobe + 3Zn
1nkx - bLTF C lobe + 2Zn + Fe
1b1x, 1f9b – hoLTF + 2Fe
1qjm – hoLTF + 2Sm
1ce2, 1biy – buLTF + 2Fe - buffalo
1i6q – cLTF + 2Fe
2bjj, 1sqy, 1n76– hLTF + 2Fe
1b0l - hLTF (mutant) + 2Fe
1fck – hLTF + 2Ce
1lfi - hLTF + 2Cu
1lct - hLTF N lobe + 2Fe
1h43, 1h44, 1h45, 1l5t, 1eh3, 1vfd, 1vfe, 1hse, 1dsn - hLTF N lobe (mutant) + 2Fe
1jw1 – LTF + 2Fe – goat
Lactoferrin binary complex
3sdf – bLTF C lobe + lipoteichoic acid + 2Zn + Fe
3rgy - bLTF C lobe + lipopolysaccharide + Zn + Fe
3kj7, 3k0v, 2q8j, 2o51, 2nwj, 2dxy, 2dwj, 2dsf, 2ds9, 2hca, 2dqv, 2dp8, 2g93, 2ays, 2alu, 2dwi, 2dyx, 2o1l, 2p1s - bLTF C lobe + polysaccharide + 2Zn + Fe
2o1l - bLTF C lobe + polysaccharide + Zn + Fe
2fa7, 2b65 - bLTF C lobe + polysaccharide + 3Zn + Fe
2dvc, 2dwa, 2dwh, 2e0s, 2e1s, 2h4i, 2px1 - bLTF C lobe + saccharide + 2Zn + Fe
2dxr - bLTF C lobe + sorbitol+ 2Zn + Fe
3iaz, 3ib0, 3ib1 - bLTF C lobe (mutant) + NSAID + 2Zn + Fe
3e9x, 2qje, 2zmb, 3crb, 2nuv - bLTF C lobe + NSAID + 2Zn + Fe
3o97, 3mjn, 3cfl, 2ocu, 3tod, 3tus – bLTF C lobe + inhibitor + 2Zn + Fe
3ib2 - bLTF C lobe (mutant) + inhibitor + 2Zn + Fe
2doj - bLTF C lobe + adenosine + 2Zn + Fe
3ci8 - bLTF C lobe + niacin + 2Zn + Fe
2r9j - bLTF C lobe + nicotinamide + 2Zn + Fe
2r71 - bLTF C lobe + inositol + 2Zn + Fe
3ttr - bLTF C lobe + anasthetic + 2Zn + Fe
3u72 - bLTF C lobe + polypeptide + 2Zn + Fe
3ptl – bLTF peptide + proteinase K
1bjr - buLTF peptide + proteinase K
1b7z - hoLTF + 2Fe + oxalate
3cr9 – hoLTF + inhibitor + 2Fe
2j4u – cLTF N terminal + OMPC
1bka - hLTF + 2Fe + oxalate
1lcf - hLTF + 2Cu + oxalate
2pms – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe
