Group:MUZIC:Plectin
From Proteopedia
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== Introduction == | == Introduction == | ||
Plectin is a multidomain protein with large size (>500kDa) and versatile binding properties, which abundantly expressed in a wide variety of mammalian tissues and cell types, combined with different binding partners. It has important functions in maintaining the mechanical stability of skin, skeletal muscle and heart. | Plectin is a multidomain protein with large size (>500kDa) and versatile binding properties, which abundantly expressed in a wide variety of mammalian tissues and cell types, combined with different binding partners. It has important functions in maintaining the mechanical stability of skin, skeletal muscle and heart. | ||
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| + | == Isoforms == | ||
| + | The plectin gene has unusual 5'-end diversity, which is alternatively spliced into exon 2 and makes 11 kinds of isoforms. | ||
| + | Expression level of isofroms is varied in tissues,and some of them are specifically expressed in brain,skeletal muscle and skin . <ref>PMID:10556294</ref>. | ||
| + | [[Image:isoforms.gif]] | ||
== Overall structure == | == Overall structure == | ||
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| - | == Isoforms == | ||
| - | The plectin gene has unusual 5'-end diversity, which is alternatively spliced into exon 2 and makes 11 kinds of isoforms. | ||
| - | Expression level of isofroms is varied in tissues,and some of them are specifically expressed in brain,skeletal muscle and skin . <ref>PMID:10556294</ref>. | ||
| - | [[Image:isoforms.gif]] | ||
== References == | == References == | ||
Revision as of 12:28, 4 July 2011
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Contents |
Introduction
Plectin is a multidomain protein with large size (>500kDa) and versatile binding properties, which abundantly expressed in a wide variety of mammalian tissues and cell types, combined with different binding partners. It has important functions in maintaining the mechanical stability of skin, skeletal muscle and heart.
Isoforms
The plectin gene has unusual 5'-end diversity, which is alternatively spliced into exon 2 and makes 11 kinds of isoforms. Expression level of isofroms is varied in tissues,and some of them are specifically expressed in brain,skeletal muscle and skin . [1].
Overall structure
Plectin can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin [2]. N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology () and .Image:Plectin structure.jpg (Litjens, 2006)
References
- ↑ Fuchs P, Zorer M, Rezniczek GA, Spazierer D, Oehler S, Castanon MJ, Hauptmann R, Wiche G. Unusual 5' transcript complexity of plectin isoforms: novel tissue-specific exons modulate actin binding activity. Hum Mol Genet. 1999 Dec;8(13):2461-72. PMID:10556294
- ↑ Foisner R, Wiche G. Structure and hydrodynamic properties of plectin molecules. J Mol Biol. 1987 Dec 5;198(3):515-31. PMID:3430617
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