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Group:MUZIC:Myostatin
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== Introduction == | == Introduction == | ||
| - | Myostatin (previously called GDF-8) was originally identified in a screen for novel mammalian members of the transforming growth factor-ß (TGF-ß) superfamily of growth and differentiation factors.The phenotype of | + | Myostatin (previously called GDF-8) was originally identified in a screen for novel mammalian members of the transforming growth factor-ß (TGF-ß) superfamily of growth and differentiation factors.The phenotype of myostatin knock-out mice suggested that myostatin functions as a negative regulator of muscle growth, and it was on this basis that myostatin was given its name <ref>PMID:9139826</ref>. For these reasons, inhibitors targeting myostatin has been regarded as potential drugs in the treatment of muscle-wasting disorders such as muscular dystrophy <ref>PMID: 18425412 </ref>. |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 14:46, 4 July 2011
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Introduction
Myostatin (previously called GDF-8) was originally identified in a screen for novel mammalian members of the transforming growth factor-ß (TGF-ß) superfamily of growth and differentiation factors.The phenotype of myostatin knock-out mice suggested that myostatin functions as a negative regulator of muscle growth, and it was on this basis that myostatin was given its name [1]. For these reasons, inhibitors targeting myostatin has been regarded as potential drugs in the treatment of muscle-wasting disorders such as muscular dystrophy [2].
References
- ↑ McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997 May 1;387(6628):83-90. PMID:9139826 doi:10.1038/387083a0
- ↑ Bradley L, Yaworsky PJ, Walsh FS. Myostatin as a therapeutic target for musculoskeletal disease. Cell Mol Life Sci. 2008 Jul;65(14):2119-24. PMID:18425412 doi:10.1007/s00018-008-8077-3
