Group:MUZIC:XIN

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-	[[2wa5]], [[3fer]], [[2eea]] - hFLNB ABD<br />	+	Xin directly binds the EVH1 domain proteins Mena and VASP.
-	[[2wa6]], [[2wa7]] - hFLNB ABD (mutant)<br />	+
-	[[2di9]], [[2dia]], [[2dib]], [[2dic]], [[2dj4]], [[2e9j]], [[2dmb]], [[2ee9]], [[2ee7]], [[2dmc]], [[2di8]], [[2dlg]], [[2e9i]], [[2ee6]], [[2eeb]], [[2eec]], [[2eed]] - hFLNB domains 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 20, 21, 22, 23, 24 – NMR<br />	+

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Revision as of 07:57, 5 July 2011

Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.

Sequence Annotation

3isw – hFLNA repeat 21+CFTR peptide – human
2wfn, 3hop, 3hor – hFLNA ABD
3hoc – hFLNA ABD (mutant)

Function

Interactions with other proteins

Xin directly binds the EVH1 domain proteins Mena and VASP.

Clinical significance

1wlh, 1qfh – FLN rod domain – Dictyostelium discoideum

References

http://www.uniprot.org/uniprot/Q702N8