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Group:MUZIC:XIN
From Proteopedia
(Difference between revisions)
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== Sequence Annotation == | == Sequence Annotation == | ||
| - | [[Image:3hop.png|left|200px|thumb|Crystal structure of Human Filamin A, [[3hop]]]] | ||
| - | {{STRUCTURE_3hop| PDB=3hop | SIZE=300| SCENE=Filamin/Cv/1 |right|CAPTION=Human Filamin A, [[3hop]] }} | ||
| - | [[Filamin]] '''A (FLNA)''' has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins. '''Filamin B (FLNB)''' is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development. '''Filamin C (FLNC)''' is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain. The images at the left and at the right correspond to one representative filamin structure, ''i.e.'' the crystal structure of human filamin A ([[3hop]]), it forms a <scene name='Filamin/Cv/2'>dimer</scene> <ref>PMID:19773341</ref>. Two phosphate ions are rendered as space filling objects. | ||
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| - | {{TOC limit|limit=2}} | ||
| - | == Filamin A == | ||
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| - | [[3isw]] – hFLNA repeat 21+CFTR peptide – human<br /> | ||
| - | [[2wfn]], [[3hop]], [[3hor]] – hFLNA ABD<br /> | ||
| - | [[3hoc]] – hFLNA ABD (mutant)<br /> | ||
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==References== | ==References== | ||
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Revision as of 08:15, 5 July 2011
Xin actin-binding repeat-containing protein 1 (Alternative name: Cardiomyopathy-associated protein 1) is coded by the gene (Synonyms:CMYA1, XIN) and has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.
Sequence Annotation
Function
Interactions with other proteins
Xin directly binds the EVH1 domain proteins Mena and VASP [2]
