3f0g
From Proteopedia
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{{STRUCTURE_3f0g| PDB=3f0g | SCENE= }} | {{STRUCTURE_3f0g| PDB=3f0g | SCENE= }} | ||
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===Co-crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase with CMP=== | ===Co-crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase with CMP=== | ||
| + | {{ABSTRACT_PUBMED_21359640}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/ISPF_BURPS ISPF_BURPS]] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107] | |
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==About this Structure== | ==About this Structure== | ||
[[3f0g]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0G OCA]. | [[3f0g]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0G OCA]. | ||
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| + | ==See Also== | ||
| + | *[[MECDP synthase|MECDP synthase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021359640</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021359640</ref><references group="xtra"/><references/> |
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]] | [[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]] | ||
[[Category: Burkholderia pseudomallei]] | [[Category: Burkholderia pseudomallei]] | ||
Revision as of 08:26, 8 May 2013
Contents |
Co-crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase with CMP
Template:ABSTRACT PUBMED 21359640
Function
[ISPF_BURPS] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107]
About this Structure
3f0g is a 6 chain structure with sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.
See Also
Reference
- Begley DW, Hartley RC, Davies DR, Edwards TE, Leonard JT, Abendroth J, Burris CA, Bhandari J, Myler PJ, Staker BL, Stewart LJ. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics. 2011 Jul;12(2):63-76. Epub 2011 Feb 26. PMID:21359640 doi:10.1007/s10969-011-9102-6
Categories: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | Burkholderia pseudomallei | SSGCID, Seattle Structural Genomics Center for Infectious Disease. | Isoprene biosynthesis | Lyase | Metal-binding | Niaid | Seattle structural genomics center for infectious disease | Ssgcid | Structural genomic
