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3sfk

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Revision as of 06:42, 17 August 2011

Image:3sfk.png

Template:STRUCTURE 3sfk

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM267

Template:ABSTRACT PUBMED 21696174

About this Structure

3sfk is a 1 chain structure with sequence from Plasmodium falciparum 3d7. Full crystallographic information is available from OCA.

Reference

  • Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford D, Barturen I, Ferrer S, Jimenez-Diaz MB, Gamo FJ, Goldsmith EJ, Charman B, Bathurst I, Floyd D, Matthews D, Burrows JN, Rathod PK, Charman SA, Phillips MA. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. J Med Chem. 2011 Jun 22. PMID:21696174 doi:10.1021/jm200592f

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OCA

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