Group:MUZIC:ZASP
From Proteopedia
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Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the '''''oracle''''' of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin.... | Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the '''''oracle''''' of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin.... | ||
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=='''Structure'''== | =='''Structure'''== | ||
Revision as of 15:58, 7 July 2011
Contents |
Introduction
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ZASP is a component protein of the striated muscle Z-disk and a member of the enigma family of proteins. Like most enigma family members, it possess an N-terminal PDZ domain and three C-terminal LIM domains. The structure of the N-terminal PDZ domain has been solved (PDB ID: 1RGW) The PDZ domain has recently been characterized to bind a very C-terminal class III motif in myotilin [1] and myozenin, two other Z-disk members prominent during myofibrillogenesis and sarcomerogenesis [[2]]. doi: 10.1083/jcb.146.2.465 http://jcb.rupress.org/content/146/2/465.full
Sequence annotation and domain topology
Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the oracle of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin.... Image:ZASP.png
Structure
ZASP PDZ domain binds.......
Function and Interactions
Mutations within the c-terminal of ZASP has been identified....
Pathology
References
Proteopedia Page Contributors and Editors (what is this?)
Adekunle Onipe, Nikos Pinotsis, Michal Harel, Jaime Prilusky
