Group:MUZIC:ZASP
From Proteopedia
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==Structure== | ==Structure== | ||
| - | <Structure load='1rgw' size='250' frame='true' align=' | + | <Structure load='1rgw' size='250' frame='true' align='right' caption='NMR solution structure of the PDZ domain of ZASP (PDB code: 1RGW)[http://www.rcsb.org/pdb/explore/explore.do?structureId=1RGW]' scene='User:Adekunle_Onipe/workbench/ZASP/Zasp_pdz_domain/3' /> |
==Function and Interactions== | ==Function and Interactions== | ||
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Mutations within the c-terminal of ZASP has been identified.... | Mutations within the c-terminal of ZASP has been identified.... | ||
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| - | == | + | ==References== |
<references/> | <references/> | ||
Revision as of 19:47, 8 July 2011
Contents |
ZASP (Z-disk Alternatively Spliced PDZ domain protein)
ZASP also referred to as LIM domain-binding protein 3 (LDB-3), is the 78 kDa, 727-amino-acid human ortholog of cypher, independently identified in heart and skeletal muscle [1]. ZASP is a component protein of the striated muscle Z-disk and a member of the enigma family of proteins. Like most enigma family members, it possess an N-terminal PDZ domain and three C-terminal LIM domains. The PDZ domain has recently been characterized to bind a very C-terminal class III motif in myotilin and myozenin. Apart from the PDZ domain, ZASP possess an internal motif (ZASP-like motif) which confers the ability to interact with the spectrin repeats of α-actinin-2 [2], suggesting it plays an important role during myofibrillogenesis.
Sequence annotation and domain topology
Canonical PDZ domains are known to target proteins to sites of complex formation, as such ZASP has been suggested as the oracle of Z-disk multi-protein complexes. This is also supported by the fact that the PDZ domain interacts with alpha-actinin-2, myotiin, myozenin.... Image:ZASP.png
Structure
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Function and Interactions
Mutations within the c-terminal of ZASP has been identified....
Pathology
References
- ↑ Faulkner G, Pallavicini A, Formentin E, Comelli A, Ievolella C, Trevisan S, Bortoletto G, Scannapieco P, Salamon M, Mouly V, Valle G, Lanfranchi G. ZASP: a new Z-band alternatively spliced PDZ-motif protein. J Cell Biol. 1999 Jul 26;146(2):465-75. PMID:10427098
- ↑ Klaavuniemi T, Ylanne J. Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin--analysis of patient mutations. Exp Cell Res. 2006 May 1;312(8):1299-311. Epub 2006 Feb 14. PMID:16476425 doi:10.1016/j.yexcr.2005.12.036
Proteopedia Page Contributors and Editors (what is this?)
Adekunle Onipe, Nikos Pinotsis, Michal Harel, Jaime Prilusky
