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2lez

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_2lez| PDB=2lez | SCENE= }}
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===Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a===
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The entry 2lez is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/PIPB2_SALTY PIPB2_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in phagocytic cells.<ref>PMID:12864852</ref> <ref>PMID:15987736</ref> <ref>PMID:16938850</ref>
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Authors: Lemak, A., Yee, A., Houliston, S., Garcia, M., Daniels, C., Savchenko, A., Arrowsmith, C., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
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==About this Structure==
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[[2lez]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEZ OCA].
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Description: Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Arrowsmith, C.]]
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[[Category: Daniels, C.]]
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[[Category: Garcia, M.]]
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[[Category: Houliston, S.]]
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[[Category: Lemak, A.]]
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[[Category: Montelione, G T.]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Savchenko, A.]]
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[[Category: Yee, A.]]
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[[Category: Bacterial effector]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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[[Category: Virulence factor]]

Revision as of 07:59, 16 May 2013

Template:STRUCTURE 2lez

Contents

Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a

Function

[PIPB2_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in phagocytic cells.[1] [2] [3]

About this Structure

2lez is a 1 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full experimental information is available from OCA.

Reference

  1. ↑ Knodler LA, Vallance BA, Hensel M, Jackel D, Finlay BB, Steele-Mortimer O. Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes. Mol Microbiol. 2003 Aug;49(3):685-704. PMID:12864852
  2. ↑ Knodler LA, Steele-Mortimer O. The Salmonella effector PipB2 affects late endosome/lysosome distribution to mediate Sif extension. Mol Biol Cell. 2005 Sep;16(9):4108-23. Epub 2005 Jun 29. PMID:15987736 doi:10.1091/mbc.E05-04-0367
  3. ↑ Henry T, Couillault C, Rockenfeller P, Boucrot E, Dumont A, Schroeder N, Hermant A, Knodler LA, Lecine P, Steele-Mortimer O, Borg JP, Gorvel JP, Meresse S. The Salmonella effector protein PipB2 is a linker for kinesin-1. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13497-502. Epub 2006 Aug 25. PMID:16938850 doi:10.1073/pnas.0605443103

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