3p0z

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[[Image:3p0z.png|left|200px]]
 
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{{STRUCTURE_3p0z| PDB=3p0z | SCENE= }}
{{STRUCTURE_3p0z| PDB=3p0z | SCENE= }}
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===Crystal structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with cytidine and FOL955, 4-(1H-imidazol)-1-yl)phenol===
===Crystal structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with cytidine and FOL955, 4-(1H-imidazol)-1-yl)phenol===
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{{ABSTRACT_PUBMED_21359640}}
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==Function==
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[[http://www.uniprot.org/uniprot/ISPF_BURP1 ISPF_BURP1]] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107]
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==About this Structure==
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[[3p0z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0Z OCA].
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(as it appears on PubMed at http://www.pubmed.gov), where 21359640 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21359640}}
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==About this Structure==
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==See Also==
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[[3p0z]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P0Z OCA].
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*[[MECDP synthase|MECDP synthase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:021359640</ref><references group="xtra"/>
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<ref group="xtra">PMID:021359640</ref><references group="xtra"/><references/>
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
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[[Category: Burkholderia pseudomallei]]
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[[Category: Burkholderia pseudomallei 1710b]]
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
[[Category: Cytidine]]
[[Category: Cytidine]]

Revision as of 08:14, 30 October 2013

Template:STRUCTURE 3p0z

Contents

Crystal structure of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei with cytidine and FOL955, 4-(1H-imidazol)-1-yl)phenol

Template:ABSTRACT PUBMED 21359640

Function

[ISPF_BURP1] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107]

About this Structure

3p0z is a 3 chain structure with sequence from Burkholderia pseudomallei 1710b. Full crystallographic information is available from OCA.

See Also

Reference

  • Begley DW, Hartley RC, Davies DR, Edwards TE, Leonard JT, Abendroth J, Burris CA, Bhandari J, Myler PJ, Staker BL, Stewart LJ. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics. 2011 Jul;12(2):63-76. Epub 2011 Feb 26. PMID:21359640 doi:10.1007/s10969-011-9102-6

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OCA

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