This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Group:MUZIC:Myopalladin
From Proteopedia
| Line 17: | Line 17: | ||
===Ig domains and their binding partners=== | ===Ig domains and their binding partners=== | ||
| - | [[Image:Myopalladin-Palladin.png |600px|right|thumb| Modular | + | [[Image:Myopalladin-Palladin.png |600px|right|thumb| Modular organisation of Myopalladin and Palladin]] |
Myopalladin comprises 5 Ig domains separated by inserted sequences for which no structural domains could be predicted from the sequence. | Myopalladin comprises 5 Ig domains separated by inserted sequences for which no structural domains could be predicted from the sequence. | ||
The only structural data related to Myopalladin are the NMR structures of Ig domain 1 (PDB code 2DM2 [[http://www.proteopedia.org/wiki/index.php/2dm2]]) and Ig domain 2 (PDB code 2DM3 [[http://www.proteopedia.org/wiki/index.php/2dm3]]) of Palladin (homologous to Ig domains 3 and 4 of Myopalladin, respectively). | The only structural data related to Myopalladin are the NMR structures of Ig domain 1 (PDB code 2DM2 [[http://www.proteopedia.org/wiki/index.php/2dm2]]) and Ig domain 2 (PDB code 2DM3 [[http://www.proteopedia.org/wiki/index.php/2dm3]]) of Palladin (homologous to Ig domains 3 and 4 of Myopalladin, respectively). | ||
| Line 30: | Line 30: | ||
Myopalladin Ig domains are separated by 6 Inserted Sequences (IS). | Myopalladin Ig domains are separated by 6 Inserted Sequences (IS). | ||
| - | The IS3 comprises a Proline-rich | + | The IS3 comprises a Proline-rich region that has been shown to interact with the SH3 domain of Nebulin and Nebulette. |
==References== | ==References== | ||
Revision as of 11:18, 13 July 2011
Contents |
Introduction
| |||||||||||
Domains and Interactions
Ig domains and their binding partners
Myopalladin comprises 5 Ig domains separated by inserted sequences for which no structural domains could be predicted from the sequence. The only structural data related to Myopalladin are the NMR structures of Ig domain 1 (PDB code 2DM2 [[1]]) and Ig domain 2 (PDB code 2DM3 [[2]]) of Palladin (homologous to Ig domains 3 and 4 of Myopalladin, respectively).
CARP
The N-terminal region of Myopalaldin, going from the N-terminal end to the domain Ig2, was shown to interact with the full length CARP.
Alpha-Actinin
The C-terminal region of Myopalaldin, going from the domain Ig3 to the very C-terminal end, was shown to interact with the EF-hand region of Alpha-Actinin.
Inserted sequences and their binding partners
Myopalladin Ig domains are separated by 6 Inserted Sequences (IS). The IS3 comprises a Proline-rich region that has been shown to interact with the SH3 domain of Nebulin and Nebulette.
References
- ↑ Bang ML, Mudry RE, McElhinny AS, Trombitas K, Geach AJ, Yamasaki R, Sorimachi H, Granzier H, Gregorio CC, Labeit S. Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies. J Cell Biol. 2001 Apr 16;153(2):413-27. PMID:11309420
