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Group:MUZIC:Myopalladin
From Proteopedia
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Revision as of 11:22, 13 July 2011
Contents |
Introduction
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Domains and Interactions
Ig domains and their binding partners
Myopalladin comprises 5 Ig domains separated by inserted sequences for which no structural domains could be predicted from the sequence. The only structural data related to Myopalladin are the NMR structures of Ig domain 1 (PDB code 2DM2 [[1]]) and Ig domain 2 (PDB code 2DM3 [[2]]) of Palladin (homologous to Ig domains 3 and 4 of Myopalladin, respectively).
CARP
The N-terminal region of Myopalaldin, going from the N-terminal end to the domain Ig2, was shown to interact with the full length CARP.
Alpha-Actinin
The C-terminal region of Myopalaldin, going from the domain Ig3 to the very C-terminal end, was shown to interact with the EF-hand region of Alpha-Actinin.
Inserted sequences and their binding partners
Myopalladin Ig domains are separated by 6 Inserted Sequences (IS). The IS3 comprises a Proline-rich region that has been shown to interact with the SH3 domain of Nebulin and Nebulette.
References
- ↑ Bang ML, Mudry RE, McElhinny AS, Trombitas K, Geach AJ, Yamasaki R, Sorimachi H, Granzier H, Gregorio CC, Labeit S. Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies. J Cell Biol. 2001 Apr 16;153(2):413-27. PMID:11309420
