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2i39

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(New page: 200px<br /><applet load="2i39" size="350" color="white" frame="true" align="right" spinBox="true" caption="2i39, resolution 2.20&Aring;" /> '''Crystal structure of...)
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==Overview==
==Overview==
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Poxviruses encode immuno-modulatory proteins capable of subverting host, defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic, regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks, detectable Bcl-2 homology (BH) motifs at the sequence level, we show that, N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2, family proteins in vitro, consistent with a role for N1L in modulating, host antiviral defenses.
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Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.
==About this Structure==
==About this Structure==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Vaccinia virus]]
[[Category: Vaccinia virus]]
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[[Category: Aleshin, A.E.]]
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[[Category: Aleshin, A E.]]
[[Category: Aoyagi, M.]]
[[Category: Aoyagi, M.]]
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[[Category: Liddington, R.C.]]
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[[Category: Liddington, R C.]]
[[Category: Stec, B.]]
[[Category: Stec, B.]]
[[Category: MPD]]
[[Category: MPD]]
[[Category: all alpha]]
[[Category: all alpha]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:34:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:48:37 2008''

Revision as of 15:48, 21 February 2008

Image:2i39.gif

2i39, resolution 2.20Å

Drag the structure with the mouse to rotate

Crystal structure of Vaccinia virus N1L protein

Overview

Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.

About this Structure

2I39 is a Single protein structure of sequence from Vaccinia virus with as ligand. Full crystallographic information is available from OCA.

Reference

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:17123957

Page seeded by OCA on Thu Feb 21 17:48:37 2008

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