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1aqw

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[[Image:1aqw.png|left|200px]]
 
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{{STRUCTURE_1aqw| PDB=1aqw | SCENE= }}
{{STRUCTURE_1aqw| PDB=1aqw | SCENE= }}
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===GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE===
===GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE===
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{{ABSTRACT_PUBMED_9351803}}
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==Function==
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[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
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{{ABSTRACT_PUBMED_9351803}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:009351803</ref><references group="xtra"/>
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<ref group="xtra">PMID:009351803</ref><references group="xtra"/><references/>
[[Category: Glutathione transferase]]
[[Category: Glutathione transferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 06:37, 10 April 2014

Template:STRUCTURE 1aqw

Contents

GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE

Template:ABSTRACT PUBMED 9351803

Function

[GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.[1]

About this Structure

1aqw is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Prade L, Huber R, Manoharan TH, Fahl WE, Reuter W. Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor. Structure. 1997 Oct 15;5(10):1287-95. PMID:9351803
  1. ↑ Sun KH, Chang KH, Clawson S, Ghosh S, Mirzaei H, Regnier F, Shah K. Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. J Neurochem. 2011 Sep;118(5):902-14. doi: 10.1111/j.1471-4159.2011.07343.x. Epub , 2011 Jul 8. PMID:21668448 doi:10.1111/j.1471-4159.2011.07343.x

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OCA

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