2lb7

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[[Image:2lb7.png|left|200px]]
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==Hevein-type Antifungal Peptide with a Unique 10-Cysteine Motif==
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<StructureSection load='2lb7' size='340' side='right' caption='[[2lb7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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[[2lb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Triticum_kiharae Triticum kiharae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LB7 OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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Hevein, a well-studied lectin from the rubber tree Hevea brasiliensis, is the title representative of a broad family of chitin-binding polypeptides. WAMP-1a, a peptide isolated from the wheat Triticum kiharae, shares considerable similarity with hevein. The peptide possesses antifungal, antibacterial activity and is thought to play an important role in the defense system of wheat. Importantly, it features a substitution of the conserved serine residue to glycine reducing its carbohydrate-binding capacity. We used NMR spectroscopy to derive the spatial structure of WAMP-1a in aqueous solution. Notably, the mutation was found to strengthen amphiphilicity of the molecule, associated with its mode of action, an indication of the hevein domain multi-functionality. Both primary and tertiary structure of WAMP-1a suggest its evolutionary origin from the hevein domain of plant chitinases.
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Solution structure of a defense peptide from wheat with a 10-cysteine motif.,Dubovskii PV, Vassilevski AA, Slavokhotova AA, Odintsova TI, Grishin EV, Egorov TA, Arseniev AS Biochem Biophys Res Commun. 2011 Jul 22;411(1):14-8. Epub 2011 Jun 14. PMID:21704019<ref>PMID:21704019</ref>
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{{STRUCTURE_2lb7| PDB=2lb7 | SCENE= }}
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===Hevein-type Antifungal Peptide with a Unique 10-Cysteine Motif===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21704019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21704019}}
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==About this Structure==
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[[2lb7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Triticum_kiharae Triticum kiharae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LB7 OCA].
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==Reference==
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<ref group="xtra">PMID:021704019</ref><ref group="xtra">PMID:019583772</ref><references group="xtra"/>
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[[Category: Triticum kiharae]]
[[Category: Triticum kiharae]]
[[Category: Arseniev, A S.]]
[[Category: Arseniev, A S.]]

Revision as of 08:42, 30 April 2014

Hevein-type Antifungal Peptide with a Unique 10-Cysteine Motif

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