3go3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3go3" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3go3.png|left|200px]]
+
==Interactions of an echinomycin-DNA complex with manganese(II) ions==
 +
<StructureSection load='3go3' size='340' side='right' caption='[[3go3]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3go3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_echinatus Streptomyces echinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GO3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GO3 FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=QUI:2-CARBOXYQUINOXALINE'>QUI</scene><br>
 +
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=N2C:N,S-DIMETHYLCYSTEINE'>N2C</scene>, <scene name='pdbligand=NCY:N-METHYLCYSTEINE'>NCY</scene></td></tr>
 +
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[185d|185d]], [[193d|193d]], [[1pfe|1pfe]], [[1vs2|1vs2]], [[1xvk|1xvk]], [[1xvn|1xvn]], [[1xvr|1xvr]], [[2adw|2adw]], [[2da8|2da8]]</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3go3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3go3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3go3 RCSB], [http://www.ebi.ac.uk/pdbsum/3go3 PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structure of an echinomycin-d(ACGTACGT) duplex interacting with manganese(II) was solved by Mn-SAD using in-house data and refined to 1.1 A resolution against synchrotron data. This complex crystallizes in a different space group compared with related complexes and shows a different mode of base pairing next to the bis-intercalation site, suggesting that the energy difference between Hoogsteen and Watson-Crick pairing is rather small. The binding of manganese to N7 of guanine is only possible because of DNA unwinding induced by the echinomycin, which might help to explain the mode of action of the drug.
-
<!--
+
Interaction of an echinomycin-DNA complex with manganese ions.,Pfoh R, Cuesta-Seijo JA, Sheldrick GM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jul 1;65(Pt, 7):660-4. Epub 2009 Jun 27. PMID:19574634<ref>PMID:19574634</ref>
-
The line below this paragraph, containing "STRUCTURE_3go3", creates the "Structure Box" on the page.
+
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
-
or leave the SCENE parameter empty for the default display.
+
-
-->
+
-
{{STRUCTURE_3go3| PDB=3go3 | SCENE= }}
+
-
===Interactions of an echinomycin-DNA complex with manganese(II) ions===
+
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_19574634}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 19574634 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_19574634}}
+
-
 
+
-
==About this Structure==
+
-
[[3go3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_echinatus Streptomyces echinatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GO3 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:019574634</ref><references group="xtra"/>
+
[[Category: Streptomyces echinatus]]
[[Category: Streptomyces echinatus]]
[[Category: Cuesta-Seijo, J A.]]
[[Category: Cuesta-Seijo, J A.]]

Revision as of 09:53, 21 May 2014

Interactions of an echinomycin-DNA complex with manganese(II) ions

3go3, resolution 1.10Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3go3"
Views
Personal tools
Navigation
Toolbox