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3pnr

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[[Image:3pnr.jpg|left|200px]]
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==Structure of PbICP-C in complex with falcipain-2==
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<StructureSection load='3pnr' size='340' side='right' caption='[[3pnr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pnr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PNR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PB000502.02.0 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5821 Plasmodium berghei])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pnr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pnr RCSB], [http://www.ebi.ac.uk/pdbsum/3pnr PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Plasmodium cysteine proteases are essential for host-cell invasion and egress, hemoglobin degradation, and intracellular development of the parasite. The temporal, site-specific regulation of cysteine-protease activity is a prerequisite for survival and propagation of Plasmodium. Recently, a new family of inhibitors of cysteine proteases (ICPs) with homologs in at least eight Plasmodium species has been identified. Here, we report the 2.6 A X-ray crystal structure of the C-terminal, inhibitory domain of ICP from P. berghei (PbICP-C) in a 1:1 complex with falcipain-2, an important hemoglobinase of Plasmodium. The structure establishes Plasmodium ICP as a member of the I42 class of chagasin-like protease inhibitors but with large insertions and differences in the binding mode relative to other family members. Furthermore, the PbICP-C structure explains why host-cell cathepsin B-like proteases and, most likely, also the protease-like domain of Plasmodium SERA5 (serine-repeat antigen 5) are no targets for ICP.
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Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium.,Hansen G, Heitmann A, Witt T, Li H, Jiang H, Shen X, Heussler VT, Rennenberg A, Hilgenfeld R Structure. 2011 Jul 13;19(7):919-29. PMID:21742259<ref>PMID:21742259</ref>
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The line below this paragraph, containing "STRUCTURE_3pnr", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3pnr| PDB=3pnr | SCENE= }}
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===Structure of PbICP-C in complex with falcipain-2===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21742259}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21742259 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21742259}}
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==About this Structure==
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[[3pnr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_berghei Plasmodium berghei] and [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PNR OCA].
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==Reference==
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<ref group="xtra">PMID:021742259</ref><references group="xtra"/>
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[[Category: Plasmodium berghei]]
[[Category: Plasmodium berghei]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]

Revision as of 05:27, 4 June 2014

Structure of PbICP-C in complex with falcipain-2

3pnr, resolution 2.60Å

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