2ygb

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[[Image:2ygb.png|left|200px]]
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==STRUCTURE OF VACCINIA VIRUS D13 SCAFFOLDING PROTEIN==
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<StructureSection load='2ygb' size='340' side='right' caption='[[2ygb]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ygb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_western_reserve Vaccinia virus western reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGB OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ygb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ygb RCSB], [http://www.ebi.ac.uk/pdbsum/2ygb PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The morphogenesis of poxviruses such as vaccinia virus (VACV) sees the virion shape mature from spherical to brick-shaped. Trimeric capsomers of the VACV D13 protein form a transitory, stabilizing lattice on the surface of the initial spherical immature virus particle. The crystal structure of D13 reveals that this major scaffolding protein comprises a double beta barrel "jelly-roll" subunit arranged as pseudo-hexagonal trimers. These structural features are characteristic of the major capsid proteins of a lineage of large icosahedral double-stranded DNA viruses including human adenovirus and the bacteriophages PRD1 and PM2. Structure-based phylogenetic analysis confirms that VACV belongs to this lineage, suggesting that (analogously to higher organism embryogenesis) early poxvirus morphogenesis reflects their evolution from a lineage of viruses sharing a common icosahedral ancestor.
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Insights into the evolution of a complex virus from the crystal structure of vaccinia virus d13.,Bahar MW, Graham SC, Stuart DI, Grimes JM Structure. 2011 Jul 13;19(7):1011-20. PMID:21742267<ref>PMID:21742267</ref>
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The line below this paragraph, containing "STRUCTURE_2ygb", creates the "Structure Box" on the page.
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{{STRUCTURE_2ygb| PDB=2ygb | SCENE= }}
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===STRUCTURE OF VACCINIA VIRUS D13 SCAFFOLDING PROTEIN===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21742267}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 21742267 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21742267}}
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==About this Structure==
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[[2ygb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_western_reserve Vaccinia virus western reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGB OCA].
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==Reference==
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<ref group="xtra">PMID:021742267</ref><references group="xtra"/>
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[[Category: Vaccinia virus western reserve]]
[[Category: Vaccinia virus western reserve]]
[[Category: Bahar, M W.]]
[[Category: Bahar, M W.]]

Revision as of 07:44, 14 May 2014

STRUCTURE OF VACCINIA VIRUS D13 SCAFFOLDING PROTEIN

2ygb, resolution 2.81Å

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