2lg1

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[[Image:2lg1.jpg|left|200px]]
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==Solution structure of the human AKAP13 PH domain and stabilizing DH helix==
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<StructureSection load='2lg1' size='340' side='right' caption='[[2lg1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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[[2lg1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LG1 OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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The human AKAP13 protein contains DH and PH domains, which are responsible for its cell transforming activity. Despite its biomedical importance, the contribution of the PH domain to AKAP13 activity remains unclear and no three dimensional structure is available to date. Here we report the backbone and side chain (1)H, (13)C and (15)N resonance assignments of a 20 kDa construct comprising the uniformly (13)C and( 15)N labeled AKAP13-PH domain and an associated helix from the DH domain which is required for its stable expression. Resonance assignment has been achieved using conventional triple resonance experiments; 95% of all back bone resonances and more than 90% of side chain resonances have been successfully assigned. The (1)H, (13)C and (15)N chemical shifts have been deposited in BMRB with accession number of 16195.
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Resonance assignments of the human AKAP13-PH domain and stabilizing DH helix.,Sugawara M, Whittaker SB, Bishop S, Ball L, Overduin M Biomol NMR Assign. 2009 Dec;3(2):215-8. Epub 2009 Jul 18. PMID:19888694<ref>PMID:19888694</ref>
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The line below this paragraph, containing "STRUCTURE_2lg1", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2lg1| PDB=2lg1 | SCENE= }}
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===Solution structure of the human AKAP13 PH domain and stabilizing DH helix===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19888694}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 19888694 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19888694}}
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==About this Structure==
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[[2lg1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LG1 OCA].
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==Reference==
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<ref group="xtra">PMID:019888694</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ball, L.]]
[[Category: Ball, L.]]

Revision as of 08:27, 30 April 2014

Solution structure of the human AKAP13 PH domain and stabilizing DH helix

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