2y8r

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[[Image:2y8r.jpg|left|200px]]
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==CRYSTAL STRUCTURE OF APO AMA1 MUTANT (TYR230ALA) FROM TOXOPLASMA GONDII==
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<StructureSection load='2y8r' size='340' side='right' caption='[[2y8r]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2y8r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8R OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y8s|2y8s]], [[2y8t|2y8t]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8r RCSB], [http://www.ebi.ac.uk/pdbsum/2y8r PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species actively invade host cells through a moving junction (MJ) complex assembled at the parasite-host cell interface. MJ assembly is initiated by injection of parasite rhoptry neck proteins (RONs) into the host cell, where RON2 spans the membrane and functions as a receptor for apical membrane antigen 1 (AMA1) on the parasite. We have determined the structure of TgAMA1 complexed with a RON2 peptide at 1.95 angstrom resolution. A stepwise assembly mechanism results in an extensive buried surface area, enabling the MJ complex to resist the mechanical forces encountered during host cell invasion. Besides providing insights into host cell invasion by apicomplexan parasites, the structure offers a basis for designing therapeutics targeting these global pathogens.
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Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.,Tonkin ML, Roques M, Lamarque MH, Pugniere M, Douguet D, Crawford J, Lebrun M, Boulanger MJ Science. 2011 Jul 22;333(6041):463-7. PMID:21778402<ref>PMID:21778402</ref>
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The line below this paragraph, containing "STRUCTURE_2y8r", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2y8r| PDB=2y8r | SCENE= }}
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===CRYSTAL STRUCTURE OF APO AMA1 MUTANT (TYR230ALA) FROM TOXOPLASMA GONDII===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21778402}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21778402 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21778402}}
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==About this Structure==
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[[2y8r]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8R OCA].
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==Reference==
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<ref group="xtra">PMID:021778402</ref><references group="xtra"/>
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[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
[[Category: Boulanger, M J.]]
[[Category: Boulanger, M J.]]

Revision as of 07:44, 14 May 2014

CRYSTAL STRUCTURE OF APO AMA1 MUTANT (TYR230ALA) FROM TOXOPLASMA GONDII

2y8r, resolution 2.45Å

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